Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 360371..360936 | Replicon | chromosome |
| Accession | NZ_CP053799 | ||
| Organism | Vibrio cholerae strain SL5Y | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | HPY14_RS15175 | Protein ID | WP_175234020.1 |
| Coordinates | 360649..360936 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D0IIK3 |
| Locus tag | HPY14_RS15170 | Protein ID | WP_000086649.1 |
| Coordinates | 360371..360652 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY14_RS15120 | 355790..355968 | + | 179 | Protein_336 | DUF645 family protein | - |
| HPY14_RS15125 | 356325..356411 | + | 87 | WP_162843093.1 | DUF645 family protein | - |
| HPY14_RS15130 | 356411..356503 | + | 93 | Protein_338 | DUF645 family protein | - |
| HPY14_RS15135 | 356705..357169 | + | 465 | WP_108244011.1 | GNAT family N-acetyltransferase | - |
| HPY14_RS15140 | 357627..357773 | + | 147 | WP_175234019.1 | DUF3265 domain-containing protein | - |
| HPY14_RS15145 | 357778..358047 | - | 270 | WP_000549239.1 | type II toxin-antitoxin system YafQ family toxin | - |
| HPY14_RS15150 | 358040..358318 | - | 279 | WP_001258568.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| HPY14_RS15155 | 358526..359062 | + | 537 | WP_019281268.1 | GNAT family N-acetyltransferase | - |
| HPY14_RS15160 | 359367..359537 | + | 171 | WP_114822807.1 | DUF645 family protein | - |
| HPY14_RS15165 | 359736..360170 | + | 435 | WP_044128155.1 | GNAT family N-acetyltransferase | - |
| HPY14_RS15170 | 360371..360652 | + | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY14_RS15175 | 360649..360936 | + | 288 | WP_175234020.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY14_RS15180 | 361105..361482 | + | 378 | WP_094392971.1 | hypothetical protein | - |
| HPY14_RS15185 | 361579..362277 | + | 699 | WP_094392972.1 | HAD family phosphatase | - |
| HPY14_RS15190 | 362549..362782 | + | 234 | WP_001999499.1 | DUF3709 domain-containing protein | - |
| HPY14_RS15195 | 363046..363876 | + | 831 | WP_100067884.1 | hypothetical protein | - |
| HPY14_RS15200 | 364019..364597 | + | 579 | WP_162298936.1 | DJ-1/PfpI family protein | - |
| HPY14_RS15205 | 364893..365075 | + | 183 | WP_094392974.1 | DUF645 family protein | - |
| HPY14_RS15210 | 365189..365284 | + | 96 | WP_088129403.1 | acetyltransferase | - |
| HPY14_RS15215 | 365316..365715 | + | 400 | Protein_355 | VOC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 307775..455729 | 147954 | |
| - | inside | Integron | - | - | 308939..456912 | 147973 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10996.80 Da Isoelectric Point: 6.8697
>T157888 WP_175234020.1 NZ_CP053799:360649-360936 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTKLLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTKLLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T157888 NZ_CP069501:1154233-1154535 [Escherichia coli]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCCGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCCGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10361.93 Da Isoelectric Point: 5.1548
>AT157888 WP_000086649.1 NZ_CP053799:360371-360652 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT157888 NZ_CP069501:1154571-1154912 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|