Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-RelB |
| Location | 357778..358318 | Replicon | chromosome |
| Accession | NZ_CP053799 | ||
| Organism | Vibrio cholerae strain SL5Y | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | HPY14_RS15145 | Protein ID | WP_000549239.1 |
| Coordinates | 357778..358047 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D7HHI1 |
| Locus tag | HPY14_RS15150 | Protein ID | WP_001258568.1 |
| Coordinates | 358040..358318 (-) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY14_RS15100 | 353383..353565 | + | 183 | WP_094392974.1 | DUF645 family protein | - |
| HPY14_RS15105 | 353712..354083 | + | 372 | WP_001891306.1 | DUF4144 domain-containing protein | - |
| HPY14_RS15110 | 354356..354565 | + | 210 | Protein_334 | DUF645 family protein | - |
| HPY14_RS15115 | 354762..355484 | + | 723 | WP_108244010.1 | hypothetical protein | - |
| HPY14_RS15120 | 355790..355968 | + | 179 | Protein_336 | DUF645 family protein | - |
| HPY14_RS15125 | 356325..356411 | + | 87 | WP_162843093.1 | DUF645 family protein | - |
| HPY14_RS15130 | 356411..356503 | + | 93 | Protein_338 | DUF645 family protein | - |
| HPY14_RS15135 | 356705..357169 | + | 465 | WP_108244011.1 | GNAT family N-acetyltransferase | - |
| HPY14_RS15140 | 357627..357773 | + | 147 | WP_175234019.1 | DUF3265 domain-containing protein | - |
| HPY14_RS15145 | 357778..358047 | - | 270 | WP_000549239.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| HPY14_RS15150 | 358040..358318 | - | 279 | WP_001258568.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HPY14_RS15155 | 358526..359062 | + | 537 | WP_019281268.1 | GNAT family N-acetyltransferase | - |
| HPY14_RS15160 | 359367..359537 | + | 171 | WP_114822807.1 | DUF645 family protein | - |
| HPY14_RS15165 | 359736..360170 | + | 435 | WP_044128155.1 | GNAT family N-acetyltransferase | - |
| HPY14_RS15170 | 360371..360652 | + | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY14_RS15175 | 360649..360936 | + | 288 | WP_175234020.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY14_RS15180 | 361105..361482 | + | 378 | WP_094392971.1 | hypothetical protein | - |
| HPY14_RS15185 | 361579..362277 | + | 699 | WP_094392972.1 | HAD family phosphatase | - |
| HPY14_RS15190 | 362549..362782 | + | 234 | WP_001999499.1 | DUF3709 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 307775..455729 | 147954 | |
| - | inside | Integron | - | - | 308939..456912 | 147973 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10380.08 Da Isoelectric Point: 9.6024
>T157887 WP_000549239.1 NZ_CP053799:c358047-357778 [Vibrio cholerae]
MHKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF
MHKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF
Download Length: 270 bp
>T157887 NZ_CP069501:c1125156-1124938 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACTATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACTATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10060.53 Da Isoelectric Point: 6.0728
>AT157887 WP_001258568.1 NZ_CP053799:c358318-358040 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHA
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHA
Download Length: 279 bp
>AT157887 NZ_CP069501:c1125556-1125182 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|