Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-phd/ParE(toxin) |
| Location | 339409..339874 | Replicon | chromosome |
| Accession | NZ_CP053799 | ||
| Organism | Vibrio cholerae strain SL5Y | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0X1KZS6 |
| Locus tag | HPY14_RS14965 | Protein ID | WP_000221354.1 |
| Coordinates | 339409..339696 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | - |
| Locus tag | HPY14_RS14970 | Protein ID | WP_175234016.1 |
| Coordinates | 339761..339874 (+) | Length | 38 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY14_RS14925 | 334717..334812 | + | 96 | WP_001907607.1 | DUF645 family protein | - |
| HPY14_RS14930 | 335637..335816 | + | 180 | WP_175234015.1 | DUF645 family protein | - |
| HPY14_RS14935 | 336062..336478 | + | 417 | WP_094393025.1 | hypothetical protein | - |
| HPY14_RS14940 | 336683..336994 | + | 312 | WP_001904684.1 | DUF3709 domain-containing protein | - |
| HPY14_RS14945 | 337283..337684 | + | 402 | WP_094393076.1 | hypothetical protein | - |
| HPY14_RS14950 | 337827..338426 | + | 600 | WP_053034786.1 | glutathione S-transferase N-terminal domain-containing protein | - |
| HPY14_RS14955 | 338771..338904 | + | 134 | Protein_303 | DUF645 family protein | - |
| HPY14_RS14960 | 339168..339419 | + | 252 | WP_046126213.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY14_RS14965 | 339409..339696 | + | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY14_RS14970 | 339761..339874 | + | 114 | WP_175234016.1 | acetyltransferase | Antitoxin |
| HPY14_RS14975 | 339840..340286 | + | 447 | WP_175234017.1 | hypothetical protein | - |
| HPY14_RS14980 | 340766..340876 | + | 111 | WP_175234065.1 | DUF3265 domain-containing protein | - |
| HPY14_RS14985 | 341063..341245 | + | 183 | WP_025987832.1 | DUF645 family protein | - |
| HPY14_RS14990 | 341360..341474 | + | 115 | Protein_310 | acetyltransferase | - |
| HPY14_RS14995 | 341423..341704 | + | 282 | WP_175234018.1 | DUF1289 domain-containing protein | - |
| HPY14_RS15000 | 341954..342382 | + | 429 | WP_053034819.1 | ester cyclase | - |
| HPY14_RS15005 | 342654..343136 | + | 483 | WP_094393003.1 | SEC-C domain-containing protein | - |
| HPY14_RS15010 | 343432..343614 | + | 183 | WP_094393107.1 | DUF645 family protein | - |
| HPY14_RS15015 | 343890..344801 | + | 912 | WP_094393008.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 307775..455729 | 147954 | |
| - | inside | Integron | - | - | 308939..456912 | 147973 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10991.96 Da Isoelectric Point: 10.4934
>T157886 WP_000221354.1 NZ_CP053799:339409-339696 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG
Download Length: 288 bp
>T157886 NZ_CP069501:c1091171-1090629 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTATTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTAATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTATTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCTGCTAAAGCTCTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAGATTGGTGTTGTCAGATTAGTCATGTTAGGGGTAGCGCG
GAAATATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTAATTTTTTTGAACATGTAAAAATAATTCACCGGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATACTCGCCTCGGCTTTGTTCAGCTTTCAGCG
AGGCCCAATGTTTTCGGTGCTGTACCGATGTTTTTAGCGATTCAGCATATTCTCGCGGCTTAG
Antitoxin
Download Length: 38 a.a. Molecular weight: 4286.05 Da Isoelectric Point: 11.8111
>AT157886 WP_175234016.1 NZ_CP053799:339761-339874 [Vibrio cholerae]
VVTVVVFEFSGMRCQPLRRALAIRGEYVGIQINRRNH
VVTVVVFEFSGMRCQPLRRALAIRGEYVGIQINRRNH
Download Length: 114 bp
>AT157886 NZ_CP069501:c1091466-1091155 [Escherichia coli]
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|