Detailed information of TA system TA157884

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 317841..318419
• Replicon: chromosome
• Accession: NZ_CP053799
• Organism: Vibrio cholerae strain SL5Y

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HPY14_RS14785
• Protein ID: WP_175234006.1
• Coordinates: 317841..318158 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: HPY14_RS14790
• Protein ID: WP_001961623.1
• Coordinates: 318177..318419 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY14_RS14740	313368..313817	+	450	WP_095465462.1	GyrI-like domain-containing protein	-
HPY14_RS14745	313976..314386	+	411	WP_095465455.1	cytidine deaminase	-
HPY14_RS14750	314525..314821	+	297	WP_000617998.1	Dabb family protein	-
HPY14_RS14755	315136..315315	+	180	WP_081020542.1	DUF645 family protein	-
HPY14_RS14760	315503..316123	+	621	WP_079881748.1	HNH endonuclease	-
HPY14_RS14765	316086..316238	+	153	WP_079881747.1	DUF3265 domain-containing protein	-
HPY14_RS14770	316425..316553	+	129	WP_080480966.1	DUF645 family protein	-
HPY14_RS14775	316569..316607	+	39	WP_108244118.1	hypothetical protein	-
HPY14_RS14780	316812..317282	+	471	WP_095465430.1	GNAT family N-acetyltransferase	-
HPY14_RS14785	317841..318158	-	318	WP_175234006.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY14_RS14790	318177..318419	-	243	WP_001961623.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY14_RS14795	318689..318925	-	237	WP_000772125.1	RNA-binding protein	-
HPY14_RS14800	319180..319953	+	774	WP_055065357.1	NERD domain-containing protein	-
HPY14_RS14805	320222..320392	+	171	WP_175234007.1	DUF3709 domain-containing protein	-
HPY14_RS14810	320727..321215	+	489	WP_059261284.1	hypothetical protein	-
HPY14_RS14815	321484..321690	+	207	Protein_275	DUF645 family protein	-
HPY14_RS14820	321889..322461	+	573	WP_042989846.1	hypothetical protein	-
HPY14_RS14825	322623..323009	+	387	WP_000703159.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	307775..455729	147954
	-	inside	Integron	-	-	308939..456912	147973

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12173.95 Da
• Isoelectric Point: 9.7495

>T157884 WP_175234006.1 NZ_CP053799:c318158-317841 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQQPQKHLKQSRFVS

Nucleotide

• Length: 318 bp

>T157884 NZ_CP069501:497118-497408 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACTGGGATATCGCCTGGTCTATTCCGTCAATGATAAAGAGTTACTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAAAACTCAGCCGTTTATGAAGACGCGACAAAACGGCTGGATGAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8931.22 Da
• Isoelectric Point: 5.6630

>AT157884 WP_001961623.1 NZ_CP053799:c318419-318177 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDGGKTVDGATFLNTL

Nucleotide

• Length: 243 bp

>AT157884 NZ_CP069501:496886-497128 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATTACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA