Detailed information of TA system TA157883

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2187370..2189195
• Replicon: chromosome
• Accession: NZ_CP053798
• Organism: Vibrio cholerae strain SL5Y

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HPY14_RS09875
• Protein ID: WP_162298882.1
• Coordinates: 2187370..2188731 (+)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HPY14_RS09880
• Protein ID: WP_046127336.1
• Coordinates: 2188728..2189195 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY14_RS09845	2182904..2184568	+	1665	WP_094392664.1	DNA repair protein RecN	-
HPY14_RS09850	2184727..2185086	+	360	WP_162298880.1	outer membrane protein assembly factor BamE	-
HPY14_RS09855	2185162..2185467	-	306	WP_001918351.1	RnfH family protein	-
HPY14_RS09860	2185470..2185904	-	435	WP_000815880.1	type II toxin-antitoxin system RatA family toxin	-
HPY14_RS09865	2186088..2186573	+	486	WP_000162689.1	SsrA-binding protein SmpB	-
HPY14_RS09875	2187370..2188731	+	1362	WP_162298882.1	type II toxin-antitoxin system HipA family toxin	Toxin
HPY14_RS09880	2188728..2189195	+	468	WP_046127336.1	helix-turn-helix domain-containing protein	Antitoxin
HPY14_RS09885	2189623..2190201	+	579	WP_094392667.1	class I SAM-dependent methyltransferase	-
HPY14_RS09890	2190205..2193126	+	2922	WP_094392668.1	DEAD/DEAH box helicase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-385)

Antitoxin

• Cro/C1-type helix-turn-helix domain (80-138)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51333.19 Da
• Isoelectric Point: 4.9109

>T157883 WP_162298882.1 NZ_CP053798:2187370-2188731 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRTEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLIRELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Nucleotide

• Length: 1362 bp

>T157883 NZ_CP069501:485714-486064 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATTTACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17077.54 Da
• Isoelectric Point: 10.7084

>AT157883 WP_046127336.1 NZ_CP053798:2188728-2189195 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDTLKSLLMDGEDG

Nucleotide

• Length: 468 bp

>AT157883 NZ_CP069501:485469-485720 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA