Detailed information of TA system TA157882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 438827..439611
• Replicon: chromosome
• Accession: NZ_CP053797
• Organism: Vibrio cholerae strain SL4G

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: HPY13_RS15910
• Protein ID: WP_001114075.1
• Coordinates: 438827..439096 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: -
• Locus tag: HPY13_RS15915
• Protein ID: WP_094393031.1
• Coordinates: 439090..439611 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY13_RS15885	434223..434720	+	498	WP_033933253.1	GNAT family N-acetyltransferase	-
HPY13_RS15890	435015..435197	+	183	Protein_474	DUF645 family protein	-
HPY13_RS15895	435478..436557	+	1080	WP_094393028.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
HPY13_RS15900	436748..437734	-	987	WP_094393029.1	sulfate ABC transporter substrate-binding protein	-
HPY13_RS15905	437996..438634	+	639	WP_094393030.1	HD domain-containing protein	-
HPY13_RS15910	438827..439096	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
HPY13_RS15915	439090..439611	+	522	WP_094393031.1	DUF2442 domain-containing protein	Antitoxin
HPY13_RS15920	439777..440517	+	741	WP_162298990.1	PhzF family phenazine biosynthesis protein	-
HPY13_RS15925	440812..440994	+	183	WP_094393107.1	DUF645 family protein	-
HPY13_RS15930	441192..441965	+	774	WP_094393066.1	aminoglycoside phosphotransferase family protein	-
HPY13_RS15935	442119..442472	+	354	WP_094393064.1	hypothetical protein	-
HPY13_RS15940	442456..443151	+	696	WP_128739199.1	hypothetical protein	-
HPY13_RS15945	443356..443619	+	264	WP_032473149.1	hypothetical protein	-
HPY13_RS15950	443845..444087	+	243	WP_033930503.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaCARB-7	-	306379..444087	137708
	-	inside	Integron	-	-	307543..445270	137727

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Uncharacterized protein HI1420 (1-173)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T157882 WP_001114075.1 NZ_CP053797:438827-439096 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T157882 NZ_CP069501:378487-378660 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGCGCATTCCTGGTCGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19455.10 Da
• Isoelectric Point: 6.7342

>AT157882 WP_094393031.1 NZ_CP053797:439090-439611 [Vibrio cholerae]
MLKVIDVDFVSDHTLELMFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELSAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT157882 NZ_CP069501:378163-378459 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A086SLD6