Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 427284..427862 | Replicon | chromosome |
| Accession | NZ_CP053797 | ||
| Organism | Vibrio cholerae strain SL4G | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | HPY13_RS15825 | Protein ID | WP_001913968.1 |
| Coordinates | 427284..427601 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7DCR7 |
| Locus tag | HPY13_RS15830 | Protein ID | WP_000557292.1 |
| Coordinates | 427620..427862 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY13_RS15785 | 422668..423144 | + | 477 | Protein_453 | GNAT family N-acetyltransferase | - |
| HPY13_RS15790 | 423439..423565 | + | 127 | Protein_454 | DUF645 family protein | - |
| HPY13_RS15795 | 423581..423619 | + | 39 | WP_108244118.1 | hypothetical protein | - |
| HPY13_RS15800 | 423814..424233 | + | 420 | WP_069730953.1 | hypothetical protein | - |
| HPY13_RS15805 | 424264..425223 | - | 960 | WP_094393086.1 | IS30 family transposase | - |
| HPY13_RS15810 | 425459..426058 | + | 600 | WP_053034786.1 | glutathione S-transferase N-terminal domain-containing protein | - |
| HPY13_RS15815 | 426358..426537 | + | 180 | WP_175234069.1 | DUF645 family protein | - |
| HPY13_RS15820 | 426742..427143 | + | 402 | WP_094393076.1 | hypothetical protein | - |
| HPY13_RS15825 | 427284..427601 | - | 318 | WP_001913968.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY13_RS15830 | 427620..427862 | - | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY13_RS15835 | 428090..428560 | - | 471 | WP_000784954.1 | RES family NAD+ phosphorylase | - |
| HPY13_RS15840 | 428560..429012 | - | 453 | WP_000024295.1 | DUF2384 domain-containing protein | - |
| HPY13_RS15845 | 429232..429768 | + | 537 | WP_094392990.1 | nucleotidyltransferase family protein | - |
| HPY13_RS15850 | 429912..430376 | + | 465 | WP_057552715.1 | GNAT family N-acetyltransferase | - |
| HPY13_RS15855 | 430669..430851 | + | 183 | WP_094392988.1 | DUF645 family protein | - |
| HPY13_RS15860 | 431067..431630 | + | 564 | WP_162813935.1 | hypothetical protein | - |
| HPY13_RS15865 | 431788..432240 | + | 453 | WP_094393102.1 | GNAT family N-acetyltransferase | - |
| HPY13_RS15870 | 432297..432692 | + | 396 | WP_162298943.1 | DUF4144 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | blaCARB-7 | - | 306379..444087 | 137708 | |
| - | inside | Integron | - | - | 307543..445270 | 137727 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12159.96 Da Isoelectric Point: 9.5425
>T157881 WP_001913968.1 NZ_CP053797:c427601-427284 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAD
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAD
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T157881 NZ_CP069501:67459-67833 [Escherichia coli]
ATGGCAAAAAGAACTGCGCTTTTTGATACCAATATCCTTATCGATTTGTTCAGCGGACGAATTGAGGCAAAACAGGCTCT
GGAGGCATGGCCCCTACAGAATGCGATTAGTCTGGTCACATGGATGGAGGTGCTGGTTGGCGCAAAAAAATATGATCAAG
AACATCGCACACGGATTGCAATGAGTGCGTTTAACGTTATTGGGATTTCGCAGGATATCGCGGAACGAAGCGTTGCTTTA
AGGCAGGAGTATAGAATGAAACTTCCAGATGCCATTATTCTGGCAACAGCACAGATTTATGGCTTTGAACTGGTAACGCG
AAATACGAGAGATTTTGCGGGAATAGCAGGTGTCGTCACACCCTATGAGCTGTAA
ATGGCAAAAAGAACTGCGCTTTTTGATACCAATATCCTTATCGATTTGTTCAGCGGACGAATTGAGGCAAAACAGGCTCT
GGAGGCATGGCCCCTACAGAATGCGATTAGTCTGGTCACATGGATGGAGGTGCTGGTTGGCGCAAAAAAATATGATCAAG
AACATCGCACACGGATTGCAATGAGTGCGTTTAACGTTATTGGGATTTCGCAGGATATCGCGGAACGAAGCGTTGCTTTA
AGGCAGGAGTATAGAATGAAACTTCCAGATGCCATTATTCTGGCAACAGCACAGATTTATGGCTTTGAACTGGTAACGCG
AAATACGAGAGATTTTGCGGGAATAGCAGGTGTCGTCACACCCTATGAGCTGTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.25 Da Isoelectric Point: 5.6630
>AT157881 WP_000557292.1 NZ_CP053797:c427862-427620 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
Download Length: 243 bp
>AT157881 NZ_CP069501:67217-67459 [Escherichia coli]
ATGAGCGCTATGGCAGGTATGGATATGGGCAGAATTTTACTCGATTTATCCGATGAGGTGATTAAGCGACTTGATGATCT
CAAAGTGCAGCGCAATCTTCCTCGCGCAGAGCTATTACGAGAAGCTGTAGATCAATATCTGGAAAATCAATCGAAAACGA
CAATATCCAGTGCTTTTGGTATCTGGCAAGGGTGTGAGGAAGATGGTGTCGAATATCAGCGTAAGCTGCGTGAGGAATGG
TAA
ATGAGCGCTATGGCAGGTATGGATATGGGCAGAATTTTACTCGATTTATCCGATGAGGTGATTAAGCGACTTGATGATCT
CAAAGTGCAGCGCAATCTTCCTCGCGCAGAGCTATTACGAGAAGCTGTAGATCAATATCTGGAAAATCAATCGAAAACGA
CAATATCCAGTGCTTTTGGTATCTGGCAAGGGTGTGAGGAAGATGGTGTCGAATATCAGCGTAAGCTGCGTGAGGAATGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|