Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 419035..419563 Replicon chromosome
Accession NZ_CP053797
Organism Vibrio cholerae strain SL4G

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag HPY13_RS15740 Protein ID WP_000221352.1
Coordinates 419035..419325 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag HPY13_RS15745 Protein ID WP_000213183.1
Coordinates 419315..419563 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY13_RS15690 414276..414560 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HPY13_RS15695 414802..415125 + 324 WP_080299109.1 DUF3709 domain-containing protein -
HPY13_RS15700 415400..415897 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
HPY13_RS15705 415894..416166 - 273 WP_001915058.1 DUF1778 domain-containing protein -
HPY13_RS15710 416412..416699 + 288 WP_094392995.1 SHOCT domain-containing protein -
HPY13_RS15715 416767..417000 + 234 WP_094392996.1 hypothetical protein -
HPY13_RS15720 417003..417119 + 117 WP_094392999.1 DUF3265 domain-containing protein -
HPY13_RS15725 417129..417644 + 516 WP_175249860.1 MazG-related protein -
HPY13_RS15730 417764..418252 + 489 WP_057561119.1 dual specificity protein phosphatase family protein -
HPY13_RS15735 418399..418908 + 510 WP_094392997.1 GNAT family N-acetyltransferase -
HPY13_RS15740 419035..419325 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY13_RS15745 419315..419563 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HPY13_RS15750 419970..420104 + 135 WP_019830500.1 DUF645 family protein -
HPY13_RS15755 420467..420691 + 225 WP_094393000.1 hypothetical protein -
HPY13_RS15760 420979..421110 + 132 WP_162298941.1 DUF3709 domain-containing protein -
HPY13_RS15765 421123..421197 + 75 WP_108244119.1 hypothetical protein -
HPY13_RS15770 421618..421749 + 132 WP_162298941.1 DUF3709 domain-containing protein -
HPY13_RS15775 421762..421836 + 75 WP_108244120.1 hypothetical protein -
HPY13_RS15780 422105..422530 + 426 WP_094393063.1 GNAT family N-acetyltransferase -
HPY13_RS15785 422668..423144 + 477 Protein_453 GNAT family N-acetyltransferase -
HPY13_RS15790 423439..423565 + 127 Protein_454 DUF645 family protein -
HPY13_RS15795 423581..423619 + 39 WP_108244118.1 hypothetical protein -
HPY13_RS15800 423814..424233 + 420 WP_069730953.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCARB-7 - 306379..444087 137708
- inside Integron - - 307543..445270 137727


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T157880 WP_000221352.1 NZ_CP053797:c419325-419035 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T157880 NZ_CP053797:c419325-419035 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCGGGCGCTGAGAATATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT157880 WP_000213183.1 NZ_CP053797:c419563-419315 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT157880 NZ_CP053797:c419563-419315 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGCGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References