Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 414001..414560 | Replicon | chromosome |
| Accession | NZ_CP053797 | ||
| Organism | Vibrio cholerae strain SL4G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0Q0N9E9 |
| Locus tag | HPY13_RS15685 | Protein ID | WP_000578475.1 |
| Coordinates | 414001..414279 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | HPY13_RS15690 | Protein ID | WP_000381183.1 |
| Coordinates | 414276..414560 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY13_RS15650 | 409322..409717 | + | 396 | WP_000870847.1 | DUF3465 domain-containing protein | - |
| HPY13_RS15655 | 409892..411025 | + | 1134 | WP_128739198.1 | RelA/SpoT domain-containing protein | - |
| HPY13_RS15660 | 411321..411503 | + | 183 | WP_108244027.1 | DUF645 family protein | - |
| HPY13_RS15665 | 411719..412282 | + | 564 | WP_162298940.1 | hypothetical protein | - |
| HPY13_RS15670 | 412587..412769 | + | 183 | WP_094392988.1 | DUF645 family protein | - |
| HPY13_RS15675 | 413121..413303 | + | 183 | WP_108244031.1 | DUF645 family protein | - |
| HPY13_RS15680 | 413486..413848 | + | 363 | WP_175234023.1 | hypothetical protein | - |
| HPY13_RS15685 | 414001..414279 | - | 279 | WP_000578475.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| HPY13_RS15690 | 414276..414560 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HPY13_RS15695 | 414802..415125 | + | 324 | WP_080299109.1 | DUF3709 domain-containing protein | - |
| HPY13_RS15700 | 415400..415897 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| HPY13_RS15705 | 415894..416166 | - | 273 | WP_001915058.1 | DUF1778 domain-containing protein | - |
| HPY13_RS15710 | 416412..416699 | + | 288 | WP_094392995.1 | SHOCT domain-containing protein | - |
| HPY13_RS15715 | 416767..417000 | + | 234 | WP_094392996.1 | hypothetical protein | - |
| HPY13_RS15720 | 417003..417119 | + | 117 | WP_094392999.1 | DUF3265 domain-containing protein | - |
| HPY13_RS15725 | 417129..417644 | + | 516 | WP_175249860.1 | MazG-related protein | - |
| HPY13_RS15730 | 417764..418252 | + | 489 | WP_057561119.1 | dual specificity protein phosphatase family protein | - |
| HPY13_RS15735 | 418399..418908 | + | 510 | WP_094392997.1 | GNAT family N-acetyltransferase | - |
| HPY13_RS15740 | 419035..419325 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | blaCARB-7 | - | 306379..444087 | 137708 | |
| - | inside | Integron | - | - | 307543..445270 | 137727 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10824.53 Da Isoelectric Point: 4.6794
>T157878 WP_000578475.1 NZ_CP053797:c414279-414001 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDEVIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDEVIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T157878 NZ_CP069500:3852947-3853261 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT157878 WP_000381183.1 NZ_CP053797:c414560-414276 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT157878 NZ_CP069500:3852711-3852944 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0N9E9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |