Detailed information of TA system TA157877

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 407100..407647
• Replicon: chromosome
• Accession: NZ_CP053797
• Organism: Vibrio cholerae strain SL4G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY13_RS15635
• Protein ID: WP_095486992.1
• Coordinates: 407345..407647 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HPY13_RS15630
• Protein ID: WP_055031549.1
• Coordinates: 407100..407357 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY13_RS15595	402434..402721	+	288	WP_001162670.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY13_RS15600	402732..403049	+	318	WP_001232701.1	HigA family addiction module antidote protein	-
HPY13_RS15605	403606..403719	+	114	Protein_417	DUF645 family protein	-
HPY13_RS15610	403937..405067	+	1131	WP_094393023.1	DUF4238 domain-containing protein	-
HPY13_RS15615	405271..405660	+	390	WP_000491261.1	VOC family protein	-
HPY13_RS15620	405745..405864	+	120	WP_162843095.1	acetyltransferase	-
HPY13_RS15625	405848..406084	-	237	WP_000772130.1	RNA-binding protein	-
HPY13_RS15630	407100..407357	+	258	WP_055031549.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY13_RS15635	407345..407647	+	303	WP_095486992.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY13_RS15640	407813..408529	+	717	WP_094393090.1	hypothetical protein	-
HPY13_RS15645	408711..409034	+	324	WP_080299109.1	DUF3709 domain-containing protein	-
HPY13_RS15650	409322..409717	+	396	WP_000870847.1	DUF3465 domain-containing protein	-
HPY13_RS15655	409892..411025	+	1134	WP_128739198.1	RelA/SpoT domain-containing protein	-
HPY13_RS15660	411321..411503	+	183	WP_108244027.1	DUF645 family protein	-
HPY13_RS15665	411719..412282	+	564	WP_162298940.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaCARB-7	-	306379..444087	137708
	-	inside	Integron	-	-	307543..445270	137727

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11771.73 Da
• Isoelectric Point: 5.8807

>T157877 WP_095486992.1 NZ_CP053797:407345-407647 [Vibrio cholerae]
MAEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYYDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T157877 NZ_CP069500:c3816001-3815849 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9619.14 Da
• Isoelectric Point: 7.3176

>AT157877 WP_055031549.1 NZ_CP053797:407100-407357 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT157877 NZ_CP069500:3816050-3816107 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA