157875

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 372244..372782 Replicon chromosome
Accession NZ_CP053797
Organism Vibrio cholerae strain SL4G

Toxin (Protein)


Gene name parE Uniprot ID A0A0N8UHD2
Locus tag HPY13_RS15330 Protein ID WP_000802131.1
Coordinates 372244..372543 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0Q0JMN6
Locus tag HPY13_RS15335 Protein ID WP_002044787.1
Coordinates 372540..372782 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY13_RS15285 367284..367796 + 513 WP_057552823.1 hypothetical protein -
HPY13_RS15290 367956..368315 + 360 WP_108244018.1 VOC family protein -
HPY13_RS15295 368603..368785 + 183 WP_001933122.1 DUF645 family protein -
HPY13_RS15300 368994..369551 + 558 WP_095488179.1 3'-5' exonuclease -
HPY13_RS15305 369548..369658 + 111 Protein_357 DUF3265 domain-containing protein -
HPY13_RS15310 369804..370295 + 492 WP_095457944.1 hypothetical protein -
HPY13_RS15315 370588..370770 + 183 WP_057556394.1 DUF645 family protein -
HPY13_RS15320 370949..371386 + 438 WP_108244019.1 hypothetical protein -
HPY13_RS15325 372111..372236 + 126 WP_095488177.1 DUF3265 domain-containing protein -
HPY13_RS15330 372244..372543 - 300 WP_000802131.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HPY13_RS15335 372540..372782 - 243 WP_002044787.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HPY13_RS15340 372830..372961 + 132 WP_080483479.1 DUF3265 domain-containing protein -
HPY13_RS15345 372990..373487 + 498 WP_094392957.1 DUF2867 domain-containing protein -
HPY13_RS15350 373792..373962 + 171 WP_094392956.1 DUF645 family protein -
HPY13_RS15355 374178..374573 + 396 WP_094392955.1 cell envelope integrity protein TolA -
HPY13_RS15360 374856..375047 + 192 WP_094392953.1 DUF3709 domain-containing protein -
HPY13_RS15365 375398..375751 + 354 WP_172626102.1 nuclear transport factor 2 family protein -
HPY13_RS15370 375897..376349 + 453 WP_000863106.1 GNAT family N-acetyltransferase -
HPY13_RS15375 376640..377053 + 414 WP_061036318.1 hypothetical protein -
HPY13_RS15380 377343..377525 + 183 WP_094392952.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCARB-7 - 306379..444087 137708
- inside Integron - - 307543..445270 137727


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11607.26 Da        Isoelectric Point: 9.9232

>T157875 WP_000802131.1 NZ_CP053797:c372543-372244 [Vibrio cholerae]
MKPFNLTTAAKTDLRDIALFTQRRWGKEQRNIYLKQFDDSFWLLAENPDIGKSCDEIRDGYRKFPQGSHVIFYQQTGSQQ
IRVVRILHKSMDVNPIFGA

Download         Length: 300 bp

>T157875 NZ_CP069500:c3689000-3688662 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAACCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTGATTAG
TAACAAAACGCCACGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8979.81 Da        Isoelectric Point: 4.1677

>AT157875 WP_002044787.1 NZ_CP053797:c372782-372540 [Vibrio cholerae]
MAKNTSITLGEHFDGFITNQIQSGRYGSASEVIRSALRLLENQETKLQTLRQLLVEGEQSGDADYDLDSFINELDSETNR

Download         Length: 243 bp

>AT157875 NZ_CP069500:3688995-3689071 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N8UHD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0JMN6

References