Detailed information of TA system TA157874

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 357896..358443
• Replicon: chromosome
• Accession: NZ_CP053797
• Organism: Vibrio cholerae strain SL4G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY13_RS15210
• Protein ID: WP_094393067.1
• Coordinates: 358141..358443 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: HPY13_RS15205
• Protein ID: WP_000861987.1
• Coordinates: 357896..358153 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY13_RS15180	353274..353537	+	264	WP_032473149.1	hypothetical protein	-
HPY13_RS15185	354269..354895	+	627	WP_095488387.1	hypothetical protein	-
HPY13_RS15190	354933..355892	-	960	WP_094393086.1	IS30 family transposase	-
HPY13_RS15195	356129..356728	+	600	WP_095464298.1	hypothetical protein	-
HPY13_RS15200	356894..357253	+	360	WP_095488206.1	VOC family protein	-
HPY13_RS15205	357896..358153	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY13_RS15210	358141..358443	+	303	WP_094393067.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY13_RS15215	358601..359149	+	549	WP_094393068.1	hypothetical protein	-
HPY13_RS15220	359268..359639	+	372	WP_162298937.1	DUF4144 domain-containing protein	-
HPY13_RS15225	359914..360150	+	237	WP_161783514.1	DUF3709 domain-containing protein	-
HPY13_RS15230	360587..360673	+	87	WP_162843094.1	DUF645 family protein	-
HPY13_RS15235	360673..360765	+	93	Protein_343	DUF645 family protein	-
HPY13_RS15240	360915..361400	+	486	WP_175249922.1	GNAT family N-acetyltransferase	-
HPY13_RS15245	361573..362163	+	591	WP_094392960.1	TIR domain-containing protein	-
HPY13_RS15250	362215..363174	-	960	WP_094393086.1	IS30 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaCARB-7	-	306379..444087	137708
	-	inside	Integron	-	-	307543..445270	137727

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11793.73 Da
• Isoelectric Point: 5.1972

>T157874 WP_094393067.1 NZ_CP053797:358141-358443 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAARQLVQTIFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T157874 NZ_CP069500:c3654480-3654223 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT157874 WP_000861987.1 NZ_CP053797:357896-358153 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT157874 NZ_CP069500:c3654211-3653660 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A1T4SLM9