Detailed information of TA system TA157872

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 341425..341965
• Replicon: chromosome
• Accession: NZ_CP053797
• Organism: Vibrio cholerae strain SL4G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY13_RS15080
• Protein ID: WP_000549239.1
• Coordinates: 341425..341694 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D7HHI1
• Locus tag: HPY13_RS15085
• Protein ID: WP_001258568.1
• Coordinates: 341687..341965 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY13_RS15035	337030..337212	+	183	WP_094392974.1	DUF645 family protein	-
HPY13_RS15040	337359..337730	+	372	WP_001891306.1	DUF4144 domain-containing protein	-
HPY13_RS15045	338003..338212	+	210	Protein_305	DUF645 family protein	-
HPY13_RS15050	338409..339131	+	723	WP_108244010.1	hypothetical protein	-
HPY13_RS15055	339437..339615	+	179	Protein_307	DUF645 family protein	-
HPY13_RS15060	339972..340058	+	87	WP_162843093.1	DUF645 family protein	-
HPY13_RS15065	340058..340150	+	93	Protein_309	DUF645 family protein	-
HPY13_RS15070	340352..340816	+	465	WP_175249857.1	GNAT family N-acetyltransferase	-
HPY13_RS15075	341274..341420	+	147	WP_175234019.1	DUF3265 domain-containing protein	-
HPY13_RS15080	341425..341694	-	270	WP_000549239.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HPY13_RS15085	341687..341965	-	279	WP_001258568.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HPY13_RS15090	342164..342712	+	549	WP_061051358.1	hypothetical protein	-
HPY13_RS15095	343009..343245	+	237	WP_161783514.1	DUF3709 domain-containing protein	-
HPY13_RS15100	343514..344341	+	828	WP_095488141.1	hypothetical protein	-
HPY13_RS15105	344500..345036	+	537	WP_019281268.1	GNAT family N-acetyltransferase	-
HPY13_RS15110	345341..345511	+	171	WP_114822807.1	DUF645 family protein	-
HPY13_RS15115	345710..346144	+	435	WP_044128155.1	GNAT family N-acetyltransferase	-
HPY13_RS15120	346345..346626	+	282	WP_000086649.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY13_RS15125	346623..346910	+	288	WP_000869999.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaCARB-7	-	306379..444087	137708
	-	inside	Integron	-	-	307543..445270	137727

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10380.08 Da
• Isoelectric Point: 9.6024

>T157872 WP_000549239.1 NZ_CP053797:c341694-341425 [Vibrio cholerae]
MHKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Nucleotide

• Length: 270 bp

>T157872 NZ_CP069500:3312461-3312634 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10060.53 Da
• Isoelectric Point: 6.0728

>AT157872 WP_001258568.1 NZ_CP053797:c341965-341687 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHA

Nucleotide

• Length: 279 bp

>AT157872 NZ_CP069500:3312137-3312433 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: D7HHI1