Detailed information of TA system TA157871

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2224795..2226620
• Replicon: chromosome
• Accession: NZ_CP053796
• Organism: Vibrio cholerae strain SL4G

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HPY13_RS10120
• Protein ID: WP_162298882.1
• Coordinates: 2224795..2226156 (+)
• Length: 454 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HPY13_RS10125
• Protein ID: WP_046127336.1
• Coordinates: 2226153..2226620 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY13_RS10090	2220327..2221991	+	1665	WP_094392664.1	DNA repair protein RecN	-
HPY13_RS10095	2222150..2222509	+	360	WP_001160907.1	outer membrane protein assembly factor BamE	-
HPY13_RS10100	2222588..2222893	-	306	WP_001918351.1	RnfH family protein	-
HPY13_RS10105	2222896..2223330	-	435	WP_000815880.1	type II toxin-antitoxin system RatA family toxin	-
HPY13_RS10110	2223513..2223998	+	486	WP_000162689.1	SsrA-binding protein SmpB	-
HPY13_RS10120	2224795..2226156	+	1362	WP_162298882.1	type II toxin-antitoxin system HipA family toxin	Toxin
HPY13_RS10125	2226153..2226620	+	468	WP_046127336.1	helix-turn-helix domain-containing protein	Antitoxin
HPY13_RS10130	2227048..2227626	+	579	WP_094392667.1	class I SAM-dependent methyltransferase	-
HPY13_RS10135	2227630..2230551	+	2922	WP_175249797.1	DEAD/DEAH box helicase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-385)

Antitoxin

• Cro/C1-type helix-turn-helix domain (80-138)

Sequences

Toxin

Protein

• Length: 454 a.a.
• Molecular weight: 51333.19 Da
• Isoelectric Point: 4.9109

>T157871 WP_162298882.1 NZ_CP053796:2224795-2226156 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRTEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLIRELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Nucleotide

• Length: 1362 bp

>T157871 NZ_CP069500:1952928-1953305 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATGCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17077.54 Da
• Isoelectric Point: 10.7084

>AT157871 WP_046127336.1 NZ_CP053796:2226153-2226620 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDTLKSLLMDGEDG

Nucleotide

• Length: 468 bp

>AT157871 NZ_CP069500:1952470-1952838 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCTGACGACAATCACGACCGCCCCTGGTGGGGACTCCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA