Detailed information of TA system TA157870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 383317..383876
• Replicon: chromosome
• Accession: NZ_CP053795
• Organism: Vibrio cholerae strain W10G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY12_RS15805
• Protein ID: WP_001897114.1
• Coordinates: 383317..383595 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9L991
• Locus tag: HPY12_RS15810
• Protein ID: WP_000381183.1
• Coordinates: 383592..383876 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY12_RS15760	378617..379054	+	438	WP_000503164.1	IS200/IS605-like element IS1004 family transposase	-
HPY12_RS15765	379118..379336	+	219	WP_071908318.1	GNAT family N-acetyltransferase	-
HPY12_RS15770	379511..380383	+	873	Protein_373	DUF3800 domain-containing protein	-
HPY12_RS15775	380533..381132	+	600	WP_001891245.1	glutathione S-transferase N-terminal domain-containing protein	-
HPY12_RS15780	381189..381293	+	105	WP_099607150.1	acetyltransferase	-
HPY12_RS15785	381324..381593	+	270	WP_001114075.1	DUF4160 domain-containing protein	-
HPY12_RS15790	381587..382108	+	522	WP_000921691.1	DUF2442 domain-containing protein	-
HPY12_RS15795	382407..382532	+	126	WP_001905700.1	DUF645 family protein	-
HPY12_RS15800	382783..383178	+	396	WP_001000868.1	hypothetical protein	-
HPY12_RS15805	383317..383595	-	279	WP_001897114.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPY12_RS15810	383592..383876	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HPY12_RS15815	384070..384585	+	516	WP_000343786.1	GNAT family N-acetyltransferase	-
HPY12_RS15820	384769..385182	+	414	WP_000049420.1	VOC family protein	-
HPY12_RS15825	385737..386916	+	1180	Protein_384	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	306166..386842	80676
	-	inside	Integron	-	-	307330..385669	78339
	-	inside	IScluster/Tn	-	-	374870..379054	4184

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10820.53 Da
• Isoelectric Point: 4.6794

>T157870 WP_001897114.1 NZ_CP053795:c383595-383317 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T157870 NZ_CP069500:c1854595-1854188 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCTCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10901.25 Da
• Isoelectric Point: 8.0775

>AT157870 WP_000381183.1 NZ_CP053795:c383876-383592 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT157870 NZ_CP069500:c1854842-1854576 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A067BL33