Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 381324..382108 Replicon chromosome
Accession NZ_CP053795
Organism Vibrio cholerae strain W10G

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag HPY12_RS15785 Protein ID WP_001114075.1
Coordinates 381324..381593 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag HPY12_RS15790 Protein ID WP_000921691.1
Coordinates 381587..382108 (+) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY12_RS15745 376648..377073 + 426 WP_001882332.1 DUF1778 domain-containing protein -
HPY12_RS15750 377070..377603 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
HPY12_RS15755 378289..378498 + 210 Protein_370 GNAT family N-acetyltransferase -
HPY12_RS15760 378617..379054 + 438 WP_000503164.1 IS200/IS605-like element IS1004 family transposase -
HPY12_RS15765 379118..379336 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
HPY12_RS15770 379511..380383 + 873 Protein_373 DUF3800 domain-containing protein -
HPY12_RS15775 380533..381132 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
HPY12_RS15780 381189..381293 + 105 WP_099607150.1 acetyltransferase -
HPY12_RS15785 381324..381593 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
HPY12_RS15790 381587..382108 + 522 WP_000921691.1 DUF2442 domain-containing protein Antitoxin
HPY12_RS15795 382407..382532 + 126 WP_001905700.1 DUF645 family protein -
HPY12_RS15800 382783..383178 + 396 WP_001000868.1 hypothetical protein -
HPY12_RS15805 383317..383595 - 279 WP_001897114.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
HPY12_RS15810 383592..383876 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HPY12_RS15815 384070..384585 + 516 WP_000343786.1 GNAT family N-acetyltransferase -
HPY12_RS15820 384769..385182 + 414 WP_000049420.1 VOC family protein -
HPY12_RS15825 385737..386916 + 1180 Protein_384 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 306166..386842 80676
- inside Integron - - 307330..385669 78339
- inside IScluster/Tn - - 374870..379054 4184


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T157869 WP_001114075.1 NZ_CP053795:381324-381593 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T157869 NZ_CP069500:c1619123-1618812 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT157869 WP_000921691.1 NZ_CP053795:381587-382108 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT157869 NZ_CP069500:c1618815-1618396 [Escherichia coli]
ATGACTGCTAATGCTGTACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGACGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB Q9KM84

References