Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DhiAT/- |
| Location | 381324..382108 | Replicon | chromosome |
| Accession | NZ_CP053795 | ||
| Organism | Vibrio cholerae strain W10G | ||
Toxin (Protein)
| Gene name | dhiT | Uniprot ID | A0A086SLD6 |
| Locus tag | HPY12_RS15785 | Protein ID | WP_001114075.1 |
| Coordinates | 381324..381593 (+) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | dhiA | Uniprot ID | Q9KM84 |
| Locus tag | HPY12_RS15790 | Protein ID | WP_000921691.1 |
| Coordinates | 381587..382108 (+) | Length | 174 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY12_RS15745 | 376648..377073 | + | 426 | WP_001882332.1 | DUF1778 domain-containing protein | - |
| HPY12_RS15750 | 377070..377603 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | - |
| HPY12_RS15755 | 378289..378498 | + | 210 | Protein_370 | GNAT family N-acetyltransferase | - |
| HPY12_RS15760 | 378617..379054 | + | 438 | WP_000503164.1 | IS200/IS605-like element IS1004 family transposase | - |
| HPY12_RS15765 | 379118..379336 | + | 219 | WP_071908318.1 | GNAT family N-acetyltransferase | - |
| HPY12_RS15770 | 379511..380383 | + | 873 | Protein_373 | DUF3800 domain-containing protein | - |
| HPY12_RS15775 | 380533..381132 | + | 600 | WP_001891245.1 | glutathione S-transferase N-terminal domain-containing protein | - |
| HPY12_RS15780 | 381189..381293 | + | 105 | WP_099607150.1 | acetyltransferase | - |
| HPY12_RS15785 | 381324..381593 | + | 270 | WP_001114075.1 | DUF4160 domain-containing protein | Toxin |
| HPY12_RS15790 | 381587..382108 | + | 522 | WP_000921691.1 | DUF2442 domain-containing protein | Antitoxin |
| HPY12_RS15795 | 382407..382532 | + | 126 | WP_001905700.1 | DUF645 family protein | - |
| HPY12_RS15800 | 382783..383178 | + | 396 | WP_001000868.1 | hypothetical protein | - |
| HPY12_RS15805 | 383317..383595 | - | 279 | WP_001897114.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| HPY12_RS15810 | 383592..383876 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| HPY12_RS15815 | 384070..384585 | + | 516 | WP_000343786.1 | GNAT family N-acetyltransferase | - |
| HPY12_RS15820 | 384769..385182 | + | 414 | WP_000049420.1 | VOC family protein | - |
| HPY12_RS15825 | 385737..386916 | + | 1180 | Protein_384 | IS3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 306166..386842 | 80676 | |
| - | inside | Integron | - | - | 307330..385669 | 78339 | |
| - | inside | IScluster/Tn | - | - | 374870..379054 | 4184 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10310.94 Da Isoelectric Point: 6.6303
>T157869 WP_001114075.1 NZ_CP053795:381324-381593 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
Download Length: 270 bp
>T157869 NZ_CP069500:c1619123-1618812 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
Antitoxin
Download Length: 174 a.a. Molecular weight: 19409.01 Da Isoelectric Point: 6.7342
>AT157869 WP_000921691.1 NZ_CP053795:381587-382108 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI
Download Length: 522 bp
>AT157869 NZ_CP069500:c1618815-1618396 [Escherichia coli]
ATGACTGCTAATGCTGTACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGACGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
ATGACTGCTAATGCTGTACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGACGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A086SLD6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q9KM84 |