Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /DUF1778(antitoxin) |
| Location | 376648..377603 | Replicon | chromosome |
| Accession | NZ_CP053795 | ||
| Organism | Vibrio cholerae strain W10G | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9KM94 |
| Locus tag | HPY12_RS15750 | Protein ID | WP_000118351.1 |
| Coordinates | 377070..377603 (+) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | HPY12_RS15745 | Protein ID | WP_001882332.1 |
| Coordinates | 376648..377073 (+) | Length | 142 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY12_RS15690 | 372311..372568 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY12_RS15695 | 372556..372858 | + | 303 | WP_000229325.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY12_RS15700 | 373146..373370 | + | 225 | WP_161571222.1 | DUF3709 domain-containing protein | - |
| HPY12_RS15705 | 373811..373897 | + | 87 | WP_134820423.1 | DUF645 family protein | - |
| HPY12_RS15710 | 373897..373989 | + | 93 | Protein_361 | DUF645 family protein | - |
| HPY12_RS15715 | 374140..374808 | + | 669 | WP_002033340.1 | hypothetical protein | - |
| HPY12_RS15720 | 374870..375307 | - | 438 | WP_000503164.1 | IS200/IS605-like element IS1004 family transposase | - |
| HPY12_RS15725 | 375421..375543 | + | 123 | WP_154591787.1 | DUF3265 domain-containing protein | - |
| HPY12_RS15730 | 375649..375684 | + | 36 | WP_172884631.1 | hypothetical protein | - |
| HPY12_RS15735 | 375702..375962 | + | 261 | WP_032468027.1 | DUF3709 domain-containing protein | - |
| HPY12_RS15740 | 376210..376581 | + | 372 | WP_001164080.1 | nucleotide pyrophosphohydrolase | - |
| HPY12_RS15745 | 376648..377073 | + | 426 | WP_001882332.1 | DUF1778 domain-containing protein | Antitoxin |
| HPY12_RS15750 | 377070..377603 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | Toxin |
| HPY12_RS15755 | 378289..378498 | + | 210 | Protein_370 | GNAT family N-acetyltransferase | - |
| HPY12_RS15760 | 378617..379054 | + | 438 | WP_000503164.1 | IS200/IS605-like element IS1004 family transposase | - |
| HPY12_RS15765 | 379118..379336 | + | 219 | WP_071908318.1 | GNAT family N-acetyltransferase | - |
| HPY12_RS15770 | 379511..380383 | + | 873 | Protein_373 | DUF3800 domain-containing protein | - |
| HPY12_RS15775 | 380533..381132 | + | 600 | WP_001891245.1 | glutathione S-transferase N-terminal domain-containing protein | - |
| HPY12_RS15780 | 381189..381293 | + | 105 | WP_099607150.1 | acetyltransferase | - |
| HPY12_RS15785 | 381324..381593 | + | 270 | WP_001114075.1 | DUF4160 domain-containing protein | - |
| HPY12_RS15790 | 381587..382108 | + | 522 | WP_000921691.1 | DUF2442 domain-containing protein | - |
| HPY12_RS15795 | 382407..382532 | + | 126 | WP_001905700.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 306166..386842 | 80676 | |
| - | inside | Integron | - | - | 307330..385669 | 78339 | |
| - | inside | IScluster/Tn | - | - | 374870..379054 | 4184 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 20171.46 Da Isoelectric Point: 9.1432
>T157867 WP_000118351.1 NZ_CP053795:377070-377603 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
Download Length: 534 bp
>T157867 NZ_CP069500:c925807-925553 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCAGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCAGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 142 a.a. Molecular weight: 15714.41 Da Isoelectric Point: 7.6659
>AT157867 WP_001882332.1 NZ_CP053795:376648-377073 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK
Download Length: 426 bp
>AT157867 NZ_CP069500:c926055-925804 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAGGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCTGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAGGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCTGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|