Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-Phd |
| Location | 372311..372858 | Replicon | chromosome |
| Accession | NZ_CP053795 | ||
| Organism | Vibrio cholerae strain W10G | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | HPY12_RS15695 | Protein ID | WP_000229325.1 |
| Coordinates | 372556..372858 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KM93 |
| Locus tag | HPY12_RS15690 | Protein ID | WP_000861987.1 |
| Coordinates | 372311..372568 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY12_RS15650 | 367764..368177 | + | 414 | WP_000049417.1 | VOC family protein | - |
| HPY12_RS15655 | 368390..368641 | + | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY12_RS15660 | 368631..368918 | + | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY12_RS15665 | 369046..369502 | + | 457 | Protein_352 | GNAT family N-acetyltransferase | - |
| HPY12_RS15670 | 369824..369976 | + | 153 | WP_001884520.1 | DUF645 family protein | - |
| HPY12_RS15675 | 370179..370676 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| HPY12_RS15680 | 370673..370945 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| HPY12_RS15685 | 371063..372022 | - | 960 | WP_001898459.1 | IS30 family transposase | - |
| HPY12_RS15690 | 372311..372568 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HPY12_RS15695 | 372556..372858 | + | 303 | WP_000229325.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HPY12_RS15700 | 373146..373370 | + | 225 | WP_161571222.1 | DUF3709 domain-containing protein | - |
| HPY12_RS15705 | 373811..373897 | + | 87 | WP_134820423.1 | DUF645 family protein | - |
| HPY12_RS15710 | 373897..373989 | + | 93 | Protein_361 | DUF645 family protein | - |
| HPY12_RS15715 | 374140..374808 | + | 669 | WP_002033340.1 | hypothetical protein | - |
| HPY12_RS15720 | 374870..375307 | - | 438 | WP_000503164.1 | IS200/IS605-like element IS1004 family transposase | - |
| HPY12_RS15725 | 375421..375543 | + | 123 | WP_154591787.1 | DUF3265 domain-containing protein | - |
| HPY12_RS15730 | 375649..375684 | + | 36 | WP_172884631.1 | hypothetical protein | - |
| HPY12_RS15735 | 375702..375962 | + | 261 | WP_032468027.1 | DUF3709 domain-containing protein | - |
| HPY12_RS15740 | 376210..376581 | + | 372 | WP_001164080.1 | nucleotide pyrophosphohydrolase | - |
| HPY12_RS15745 | 376648..377073 | + | 426 | WP_001882332.1 | DUF1778 domain-containing protein | - |
| HPY12_RS15750 | 377070..377603 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 306166..386842 | 80676 | |
| - | inside | Integron | - | - | 307330..385669 | 78339 | |
| - | inside | IScluster/Tn | - | - | 374870..379054 | 4184 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11710.64 Da Isoelectric Point: 5.1972
>T157866 WP_000229325.1 NZ_CP053795:372556-372858 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T157866 NZ_CP069500:906681-907055 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCTGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCTGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT157866 WP_000861987.1 NZ_CP053795:372311-372568 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT157866 NZ_CP069500:906224-906592 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|