Detailed information of TA system TA157866

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 372311..372858
• Replicon: chromosome
• Accession: NZ_CP053795
• Organism: Vibrio cholerae strain W10G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPY12_RS15695
• Protein ID: WP_000229325.1
• Coordinates: 372556..372858 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: HPY12_RS15690
• Protein ID: WP_000861987.1
• Coordinates: 372311..372568 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY12_RS15650	367764..368177	+	414	WP_000049417.1	VOC family protein	-
HPY12_RS15655	368390..368641	+	252	WP_001250179.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HPY12_RS15660	368631..368918	+	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY12_RS15665	369046..369502	+	457	Protein_352	GNAT family N-acetyltransferase	-
HPY12_RS15670	369824..369976	+	153	WP_001884520.1	DUF645 family protein	-
HPY12_RS15675	370179..370676	-	498	WP_000982260.1	GNAT family N-acetyltransferase	-
HPY12_RS15680	370673..370945	-	273	WP_000246253.1	DUF1778 domain-containing protein	-
HPY12_RS15685	371063..372022	-	960	WP_001898459.1	IS30 family transposase	-
HPY12_RS15690	372311..372568	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY12_RS15695	372556..372858	+	303	WP_000229325.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY12_RS15700	373146..373370	+	225	WP_161571222.1	DUF3709 domain-containing protein	-
HPY12_RS15705	373811..373897	+	87	WP_134820423.1	DUF645 family protein	-
HPY12_RS15710	373897..373989	+	93	Protein_361	DUF645 family protein	-
HPY12_RS15715	374140..374808	+	669	WP_002033340.1	hypothetical protein	-
HPY12_RS15720	374870..375307	-	438	WP_000503164.1	IS200/IS605-like element IS1004 family transposase	-
HPY12_RS15725	375421..375543	+	123	WP_154591787.1	DUF3265 domain-containing protein	-
HPY12_RS15730	375649..375684	+	36	WP_172884631.1	hypothetical protein	-
HPY12_RS15735	375702..375962	+	261	WP_032468027.1	DUF3709 domain-containing protein	-
HPY12_RS15740	376210..376581	+	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
HPY12_RS15745	376648..377073	+	426	WP_001882332.1	DUF1778 domain-containing protein	-
HPY12_RS15750	377070..377603	+	534	WP_000118351.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	306166..386842	80676
	-	inside	Integron	-	-	307330..385669	78339
	-	inside	IScluster/Tn	-	-	374870..379054	4184

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11710.64 Da
• Isoelectric Point: 5.1972

>T157866 WP_000229325.1 NZ_CP053795:372556-372858 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T157866 NZ_CP069500:906681-907055 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCTGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT157866 WP_000861987.1 NZ_CP053795:372311-372568 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT157866 NZ_CP069500:906224-906592 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1T4SLM9