Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc(toxin) |
| Location | 362643..363214 | Replicon | chromosome |
| Accession | NZ_CP053795 | ||
| Organism | Vibrio cholerae strain W10G | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9KMA2 |
| Locus tag | HPY12_RS15610 | Protein ID | WP_000351248.1 |
| Coordinates | 362813..363214 (+) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q8GNG3 |
| Locus tag | HPY12_RS15605 | Protein ID | WP_001080654.1 |
| Coordinates | 362643..362813 (+) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HPY12_RS15560 | 357787..358302 | + | 516 | WP_000090010.1 | hypothetical protein | - |
| HPY12_RS15565 | 358564..358800 | + | 237 | Protein_332 | DUF3709 domain-containing protein | - |
| HPY12_RS15570 | 359088..359417 | + | 330 | WP_043990318.1 | DHCW motif cupin fold protein | - |
| HPY12_RS15575 | 359728..359853 | + | 126 | WP_080285473.1 | DUF645 family protein | - |
| HPY12_RS15580 | 359869..359907 | + | 39 | WP_148506239.1 | hypothetical protein | - |
| HPY12_RS15585 | 360092..360382 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HPY12_RS15590 | 360372..360620 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HPY12_RS15595 | 360862..361185 | + | 324 | WP_080375416.1 | DUF3709 domain-containing protein | - |
| HPY12_RS15600 | 361459..362463 | + | 1005 | WP_000964934.1 | LD-carboxypeptidase | - |
| HPY12_RS15605 | 362643..362813 | + | 171 | WP_001080654.1 | hypothetical protein | Antitoxin |
| HPY12_RS15610 | 362813..363214 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| HPY12_RS15615 | 363184..363327 | + | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
| HPY12_RS15620 | 363413..363664 | + | 252 | WP_088124792.1 | TIGR03643 family protein | - |
| HPY12_RS15625 | 363828..364673 | + | 846 | WP_057569090.1 | hypothetical protein | - |
| HPY12_RS15630 | 364839..365477 | + | 639 | WP_057569094.1 | HD domain-containing protein | - |
| HPY12_RS15635 | 365632..366171 | + | 540 | WP_057569092.1 | phosphoglycerate mutase family protein | - |
| HPY12_RS15640 | 366261..366842 | + | 582 | WP_043990376.1 | nucleotidyltransferase family protein | - |
| HPY12_RS15645 | 366980..367579 | + | 600 | WP_043990194.1 | glutathione S-transferase N-terminal domain-containing protein | - |
| HPY12_RS15650 | 367764..368177 | + | 414 | WP_000049417.1 | VOC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 306166..386842 | 80676 | |
| - | inside | Integron | - | - | 307330..385669 | 78339 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14608.71 Da Isoelectric Point: 4.0128
>T157863 WP_000351248.1 NZ_CP053795:362813-363214 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
Download Length: 402 bp
>T157863 NZ_CP069500:c295923-295645 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6287.35 Da Isoelectric Point: 10.7274
>AT157863 WP_001080654.1 NZ_CP053795:362643-362813 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
Download Length: 171 bp
>AT157863 NZ_CP069500:c295645-295361 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0PN34 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SJJ1 |