Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 362643..363214 Replicon chromosome
Accession NZ_CP053795
Organism Vibrio cholerae strain W10G

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag HPY12_RS15610 Protein ID WP_000351248.1
Coordinates 362813..363214 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag HPY12_RS15605 Protein ID WP_001080654.1
Coordinates 362643..362813 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY12_RS15560 357787..358302 + 516 WP_000090010.1 hypothetical protein -
HPY12_RS15565 358564..358800 + 237 Protein_332 DUF3709 domain-containing protein -
HPY12_RS15570 359088..359417 + 330 WP_043990318.1 DHCW motif cupin fold protein -
HPY12_RS15575 359728..359853 + 126 WP_080285473.1 DUF645 family protein -
HPY12_RS15580 359869..359907 + 39 WP_148506239.1 hypothetical protein -
HPY12_RS15585 360092..360382 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin -
HPY12_RS15590 360372..360620 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HPY12_RS15595 360862..361185 + 324 WP_080375416.1 DUF3709 domain-containing protein -
HPY12_RS15600 361459..362463 + 1005 WP_000964934.1 LD-carboxypeptidase -
HPY12_RS15605 362643..362813 + 171 WP_001080654.1 hypothetical protein Antitoxin
HPY12_RS15610 362813..363214 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HPY12_RS15615 363184..363327 + 144 WP_071908341.1 DUF3265 domain-containing protein -
HPY12_RS15620 363413..363664 + 252 WP_088124792.1 TIGR03643 family protein -
HPY12_RS15625 363828..364673 + 846 WP_057569090.1 hypothetical protein -
HPY12_RS15630 364839..365477 + 639 WP_057569094.1 HD domain-containing protein -
HPY12_RS15635 365632..366171 + 540 WP_057569092.1 phosphoglycerate mutase family protein -
HPY12_RS15640 366261..366842 + 582 WP_043990376.1 nucleotidyltransferase family protein -
HPY12_RS15645 366980..367579 + 600 WP_043990194.1 glutathione S-transferase N-terminal domain-containing protein -
HPY12_RS15650 367764..368177 + 414 WP_000049417.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 306166..386842 80676
- inside Integron - - 307330..385669 78339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T157863 WP_000351248.1 NZ_CP053795:362813-363214 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T157863 NZ_CP069500:c295923-295645 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT157863 WP_001080654.1 NZ_CP053795:362643-362813 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT157863 NZ_CP069500:c295645-295361 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References