Detailed information of TA system TA157862

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 360092..360620
• Replicon: chromosome
• Accession: NZ_CP053795
• Organism: Vibrio cholerae strain W10G

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H9L4R3
• Locus tag: HPY12_RS15585
• Protein ID: WP_000221352.1
• Coordinates: 360092..360382 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H9L4T4
• Locus tag: HPY12_RS15590
• Protein ID: WP_000213183.1
• Coordinates: 360372..360620 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPY12_RS15535	355097..355612	+	516	Protein_326	ClbS/DfsB family four-helix bundle protein	-
HPY12_RS15540	355920..356102	+	183	WP_043992545.1	DUF645 family protein	-
HPY12_RS15545	356391..356816	+	426	WP_001898239.1	hypothetical protein	-
HPY12_RS15550	357052..357339	+	288	WP_001162670.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HPY12_RS15555	357350..357667	+	318	WP_001898235.1	HigA family addiction module antidote protein	-
HPY12_RS15560	357787..358302	+	516	WP_000090010.1	hypothetical protein	-
HPY12_RS15565	358564..358800	+	237	Protein_332	DUF3709 domain-containing protein	-
HPY12_RS15570	359088..359417	+	330	WP_043990318.1	DHCW motif cupin fold protein	-
HPY12_RS15575	359728..359853	+	126	WP_080285473.1	DUF645 family protein	-
HPY12_RS15580	359869..359907	+	39	WP_148506239.1	hypothetical protein	-
HPY12_RS15585	360092..360382	-	291	WP_000221352.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPY12_RS15590	360372..360620	-	249	WP_000213183.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HPY12_RS15595	360862..361185	+	324	WP_080375416.1	DUF3709 domain-containing protein	-
HPY12_RS15600	361459..362463	+	1005	WP_000964934.1	LD-carboxypeptidase	-
HPY12_RS15605	362643..362813	+	171	WP_001080654.1	hypothetical protein	-
HPY12_RS15610	362813..363214	+	402	WP_000351248.1	type II toxin-antitoxin system death-on-curing family toxin	-
HPY12_RS15615	363184..363327	+	144	WP_071908341.1	DUF3265 domain-containing protein	-
HPY12_RS15620	363413..363664	+	252	WP_088124792.1	TIGR03643 family protein	-
HPY12_RS15625	363828..364673	+	846	WP_057569090.1	hypothetical protein	-
HPY12_RS15630	364839..365477	+	639	WP_057569094.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	306166..386842	80676
	-	inside	Integron	-	-	307330..385669	78339

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11247.23 Da
• Isoelectric Point: 10.4678

>T157862 WP_000221352.1 NZ_CP053795:c360382-360092 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Nucleotide

• Length: 291 bp

>T157862 NZ_CP069500:c73169-73062 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8937.28 Da
• Isoelectric Point: 4.1079

>AT157862 WP_000213183.1 NZ_CP053795:c360620-360372 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Nucleotide

• Length: 249 bp

>AT157862 NZ_CP069500:73222-73283 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: H9L4R3

Antitoxin

• AlphaFold DB: A0A366A3W8