Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2267482..2269307 Replicon chromosome
Accession NZ_CP053794
Organism Vibrio cholerae strain W10G

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HPY12_RS10350 Protein ID WP_057569042.1
Coordinates 2267482..2268843 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HPY12_RS10355 Protein ID WP_032472658.1
Coordinates 2268840..2269307 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPY12_RS10320 2263016..2264680 + 1665 WP_000879550.1 DNA repair protein RecN -
HPY12_RS10325 2264839..2265198 + 360 WP_001160907.1 outer membrane protein assembly factor BamE -
HPY12_RS10330 2265274..2265579 - 306 WP_001918351.1 RnfH family protein -
HPY12_RS10335 2265582..2266016 - 435 WP_000815880.1 type II toxin-antitoxin system RatA family toxin -
HPY12_RS10340 2266200..2266685 + 486 WP_000162689.1 SsrA-binding protein SmpB -
HPY12_RS10350 2267482..2268843 + 1362 WP_057569042.1 type II toxin-antitoxin system HipA family toxin Toxin
HPY12_RS10355 2268840..2269307 + 468 WP_032472658.1 helix-turn-helix domain-containing protein Antitoxin
HPY12_RS10360 2269899..2271932 + 2034 WP_057569040.1 DNA phosphorothioation-associated putative methyltransferase -
HPY12_RS10365 2271992..2273032 - 1041 WP_057569038.1 IS481 family transposase -
HPY12_RS10370 2273142..2273945 - 804 WP_057568910.1 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2271992..2273032 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-383)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51242.13 Da        Isoelectric Point: 4.7953

>T157858 WP_057569042.1 NZ_CP053794:2267482-2268843 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQYNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRALIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVITLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T157858 NZ_CP069498:115308-115496 [Acinetobacter pittii]
ATGAGTAAAGGACTATTTGAGTTGCGCTTAAAATCTCAAGAAGGTATTGCTCGTGTTATGTATTGCACACTAGTCGGTAA
ACGCATTGTAATGCTCCATAGTTTTGTTAAGAAAACCCAAAAAACACCTAAGCAAGATCTAAACCTAGCACTTGACCGCA
TGAAAGAGGTGAAAAATGCGAACACATGA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17073.60 Da        Isoelectric Point: 10.7084

>AT157858 WP_032472658.1 NZ_CP053794:2268840-2269307 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKNATHSIKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp

>AT157858 NZ_CP069498:115483-115770 [Acinetobacter pittii]
ATGCGAACACATGAAGAAATGAAAGCACTTGCATTATCTCGTTCAGCAGTGCGTACCGAATACGAACGAATTGAACGTGA
AGAAATGCCCTTGCTCGATATGGTACTTACTGCACTTCGAGAGGCAGGTCTATCCCAAGCGCAAATCGCGGAACGCATGG
GAACAAATGTACCTGCCGTTTCACGGCTAGAAAAAGCATTGATCACAGGCAAACCATCACCATCTATTGCCACATTGCAA
AAATATGCTGCGGCAATTGGTAAACATGTTGAAGTGCGTTTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References