Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1139093..1139705 Replicon chromosome
Accession NZ_CP053792
Organism Streptococcus canis strain HL_77_1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag GE021_RS05735 Protein ID WP_125073953.1
Coordinates 1139093..1139428 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Q8EDD0
Locus tag GE021_RS05740 Protein ID WP_017648215.1
Coordinates 1139418..1139705 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE021_RS05710 1134478..1134837 - 360 WP_003048644.1 dihydroneopterin aldolase -
GE021_RS05715 1134844..1135644 - 801 WP_125073956.1 dihydropteroate synthase -
GE021_RS05720 1135653..1136219 - 567 WP_125073955.1 GTP cyclohydrolase I FolE -
GE021_RS05725 1136251..1137519 - 1269 WP_125073954.1 bifunctional folylpolyglutamate synthase/dihydrofolate synthase -
GE021_RS05730 1137610..1138470 - 861 Protein_1090 homoserine kinase -
GE021_RS05735 1139093..1139428 - 336 WP_125073953.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GE021_RS05740 1139418..1139705 - 288 WP_017648215.1 hypothetical protein Antitoxin
GE021_RS05745 1139881..1140323 - 443 Protein_1093 hypothetical protein -
GE021_RS05750 1140509..1141477 + 969 WP_125073952.1 polysaccharide deacetylase family protein -
GE021_RS05755 1141584..1142819 - 1236 WP_125073951.1 D-alanyl-D-alanine carboxypeptidase PBP3 -
GE021_RS05760 1143137..1144342 - 1206 WP_125073950.1 30S ribosomal protein S1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13215.98 Da        Isoelectric Point: 5.2388

>T157854 WP_125073953.1 NZ_CP053792:c1139428-1139093 [Streptococcus canis]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPARSDYIKLFK

Download         Length: 336 bp

>T157854 NZ_CP069497:4005-4295 [Acinetobacter pittii]
ATGACACTGACGATTAGGTACAAGAAACAATTTAAAAAAGATTTTAAACGGGTAAGCTCAAACCCAAAGCTTAAGAAAGG
ACTCTTAATTTTGAAGGATCTTATTGATGAGCATTTGGTAAAAACAGGGACTGTTCCAGATGAGTATTTACCTCATCCTT
TGATTGGTGAGTGGAAACCCCATATGGAATGCCATATTTTACCTGATTTATTATTAATTTGGGATGTGGATGAAGATAAT
AATGAGCTAATACTTGCTCGGATTGGATCTCATTCTGAACTTTTTGGATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10949.53 Da        Isoelectric Point: 4.7271

>AT157854 WP_017648215.1 NZ_CP053792:c1139705-1139418 [Streptococcus canis]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT157854 NZ_CP069497:3746-4021 [Acinetobacter pittii]
ATGAATACTTTGGCAAAAAAAGATGAGTATGTACGTGCTAGGGTTCCAAATGAATTAAAGGTTCAAGCGGAGCGAATTCT
AAAAGAAGTGGGTTTAAATACTACAGATGCTATTCGCTTATTATTAACGCAAGTAGTAAATCGAGGTGGATTTCCTTTAG
AGTTAAGAACCCCTAACCGTACAACAATTGAGGCTATGAACTCTGTTGCAGAACCTAAAAAATTTAGTTCTGCTCAGGAA
TTGTTTACGGATTTAGAAGATGACACTGACGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8EDD0

References