Detailed information of TA system TA157852

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2102268..2102754
• Replicon: chromosome
• Accession: NZ_CP053790
• Organism: Streptococcus canis strain HL_77_2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q48QR0
• Locus tag: GE022_RS10160
• Protein ID: WP_014407961.1
• Coordinates: 2102268..2102537 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A660A1J7
• Locus tag: GE022_RS10165
• Protein ID: WP_014407962.1
• Coordinates: 2102527..2102754 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GE022_RS10145	2097422..2098504	+	1083	WP_164405174.1	DUF4097 domain-containing protein	-
GE022_RS10150	2098820..2101084	-	2265	WP_164405173.1	YhgE/Pip domain-containing protein	-
GE022_RS10155	2101219..2101752	+	534	WP_164405172.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
GE022_RS10160	2102268..2102537	-	270	WP_014407961.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GE022_RS10165	2102527..2102754	-	228	WP_014407962.1	hypothetical protein	Antitoxin
GE022_RS10170	2102907..2103278	-	372	WP_011285302.1	DUF1492 domain-containing protein	-
GE022_RS10175	2103268..2103615	-	348	WP_011285303.1	DUF1492 domain-containing protein	-
GE022_RS10180	2103893..2104138	-	246	WP_011285304.1	hypothetical protein	-
GE022_RS10185	2104113..2104388	-	276	WP_014407964.1	hypothetical protein	-
GE022_RS10190	2104378..2104716	-	339	WP_030126557.1	replication protein	-
GE022_RS10195	2104758..2105024	-	267	WP_011285307.1	hypothetical protein	-
GE022_RS10200	2105021..2105809	-	789	WP_011285308.1	hypothetical protein	-
GE022_RS10205	2105900..2106058	-	159	WP_011285309.1	hypothetical protein	-
GE022_RS10210	2106072..2106317	-	246	WP_011285310.1	hypothetical protein	-
GE022_RS10215	2106313..2106639	-	327	Protein_1956	hypothetical protein	-
GE022_RS10220	2106641..2106814	-	174	WP_164405171.1	hypothetical protein	-
GE022_RS10225	2106820..2106993	-	174	WP_000694580.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2092530..2117372	24842

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10497.50 Da
• Isoelectric Point: 10.5027

>T157852 WP_014407961.1 NZ_CP053790:c2102537-2102268 [Streptococcus canis]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Nucleotide

• Length: 270 bp

>T157852 NZ_CP069496:c1555984-1555802 [Acinetobacter pittii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8641.63 Da
• Isoelectric Point: 3.9607

>AT157852 WP_014407962.1 NZ_CP053790:c2102754-2102527 [Streptococcus canis]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Nucleotide

• Length: 228 bp

>AT157852 NZ_CP069496:c1555709-1555305 [Acinetobacter pittii]
ATGTTATATCTAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: A0A660A202

Antitoxin

• AlphaFold DB: A0A660A1J7