Detailed information of TA system TA157851

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1105520..1106952
• Replicon: chromosome
• Accession: NZ_CP053790
• Organism: Streptococcus canis strain HL_77_2

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: GE022_RS05390
• Protein ID: WP_164227787.1
• Coordinates: 1106107..1106952 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: GE022_RS05385
• Protein ID: WP_164227788.1
• Coordinates: 1105520..1106110 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GE022_RS05385	1105520..1106110	+	591	WP_164227788.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
GE022_RS05390	1106107..1106952	+	846	WP_164227787.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
GE022_RS05395	1107016..1109814	-	2799	WP_164405383.1	CHAP domain-containing protein	-
GE022_RS05400	1109816..1110835	-	1020	WP_164405402.1	type IV secretion system protein VirB4	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32447.14 Da
• Isoelectric Point: 5.4155

>T157851 WP_164227787.1 NZ_CP053790:1106107-1106952 [Streptococcus canis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQMTLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFAKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLSDVLDEMIHLITVLISINSD

Nucleotide

• Length: 846 bp

>T157851 NZ_CP069495:2135645-2136052 [Kytococcus sedentarius]
GTGAACACCCTGATCGCCTTGCTCGACATCGATCACCGTGACCATGAGGCCGCCCACCGATGGGCTGAAGAACGCCTCTC
GAACGGGTGGGCCACCTGTGCCACGACACAAATGGGCTTCCTCCGTGTCATCAGCCAGCCGGGTTACCCCAGTCCCATCA
CAGTGGACGAGGCCGGACGCCTGCTCCGACGAGCGACCGACCACCCCTCGCACGAGTACTGGAGCTCGGAACCACAGCCC
TGTGCCGGCTCCGTGTCCCTCGATGTGATCACGGGCCACCGCCAGATCACGGATGCGTACCTGCTTGCCCTTGCCGTGCA
CCAGAACGGGTGCCTGGTGACCTTTGACCGACGCATCACCACTCGGCACGTCCCAGGGGCCGGCCAGGAGCACTTGGTCA
GACTGTGA

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23268.80 Da
• Isoelectric Point: 7.3116

>AT157851 WP_164227788.1 NZ_CP053790:1105520-1106110 [Streptococcus canis]
MSKKEILLEFIENHNGIITYKDCKALKVPTIYLTRLEKEGIIYRIEKGIFLTQNGDYDEYFFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGTTLVKTPMGNEVRVYDFERIICDFVIHRETIDTELFVKT
LQHYGNYPKKNLTKLYEYATKMNTLDKVKQTLEVLI

Nucleotide

• Length: 591 bp

>AT157851 NZ_CP069495:2135395-2135625 [Kytococcus sedentarius]
ATGCGTACGACACTCACCATCGAGGACGACGTGCTCCAGGCCGTCAAGGACCGCGCTCGCGCCCGTGGGACCACGGCCGG
GCAGGAACTGTCGGCCCTTGCCCGTGCTGCTCTGTCCGCGCCGACGTTCGTTGACGTGGGTGAACGCAACGGCCTCCCGG
TTCTCCAGCACCGTGGGGAACCCGTCACACGTGAGCAGGTAGAGGCCCTTCTCGATGAGGACCCAGCCTGA