157850

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1033601..1034213 Replicon chromosome
Accession NZ_CP053790
Organism Streptococcus canis strain HL_77_2

Toxin (Protein)


Gene name parE Uniprot ID A0A4V0C1F2
Locus tag GE022_RS05080 Protein ID WP_003048651.1
Coordinates 1033601..1033936 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A4V0C2C3
Locus tag GE022_RS05085 Protein ID WP_003048654.1
Coordinates 1033926..1034213 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE022_RS05055 1028985..1029344 - 360 WP_003048644.1 dihydroneopterin aldolase -
GE022_RS05060 1029351..1030151 - 801 WP_164227972.1 dihydropteroate synthase -
GE022_RS05065 1030160..1030726 - 567 WP_164405366.1 GTP cyclohydrolase I FolE -
GE022_RS05070 1030758..1032026 - 1269 WP_164405367.1 bifunctional folylpolyglutamate synthase/dihydrofolate synthase -
GE022_RS05075 1032117..1032978 - 862 Protein_941 homoserine kinase -
GE022_RS05080 1033601..1033936 - 336 WP_003048651.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GE022_RS05085 1033926..1034213 - 288 WP_003048654.1 hypothetical protein Antitoxin
GE022_RS05090 1034388..1034830 - 443 Protein_944 hypothetical protein -
GE022_RS05095 1035016..1035984 + 969 WP_003048658.1 polysaccharide deacetylase family protein -
GE022_RS05100 1036096..1037331 - 1236 WP_172758323.1 D-alanyl-D-alanine carboxypeptidase PBP3 -
GE022_RS05105 1037649..1038854 - 1206 WP_159305048.1 30S ribosomal protein S1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13215.04 Da        Isoelectric Point: 6.2385

>T157850 WP_003048651.1 NZ_CP053790:c1033936-1033601 [Streptococcus canis]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLKVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPARSDYIKLFK

Download         Length: 336 bp

>T157850 NZ_CP069495:c2061279-2061013 [Kytococcus sedentarius]
TTGGCCTGGACCGTTGAGGTCTCGGCGACGGCGCGCAAGGCGCTGAAGAAGCTGGGCCCACCGGTGGCCCGCCGCATCGT
CCGCTTCCTGCGGGAGCTCGAGGCGCTGGACGATCCGCGGGCCCGAGGCAAGGCCCTCACGGGGGTTCTGTCCGGGCTGT
GGCGCTACCGGGTCGGGGACCACCGGGTCATCTGTGACCTGGACGACGAGGTCCTCGTCGTCCACGTCATCGAGGTCGGG
CACCGCTCCTCGGTGTACGACGACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10977.54 Da        Isoelectric Point: 4.6036

>AT157850 WP_003048654.1 NZ_CP053790:c1034213-1033926 [Streptococcus canis]
MVEVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT157850 NZ_CP069495:c2061496-2061263 [Kytococcus sedentarius]
ATGACCGTCGCCACCTCCGTGAAGCTGTCCGACGAGACCGGCCGCAAGCTCGAGCAGCTGGCCGCCGCCACCGGGCGCTC
GAAGTCCTACTACCTCCGCGAGGCCGTGGAGACCCACATCGACCGCCTCCTCTACGAGTACGGCATCGTCCAGCGGGTCG
AGGATGTCCGCGCCGGCCGCGAGGCCACCTACGGTCTCGACGAGGTGGAGGCGGATCTTGGCCTGGACCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V0C1F2

Antitoxin

Source ID Structure
AlphaFold DB A0A4V0C2C3

References