Detailed information of TA system TA157849

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 128239..128916
• Replicon: chromosome
• Accession: NZ_CP053790
• Organism: Streptococcus canis strain HL_77_2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: V6Z2K9
• Locus tag: GE022_RS00810
• Protein ID: WP_015647112.1
• Coordinates: 128239..128421 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GE022_RS00815
• Protein ID: WP_093998740.1
• Coordinates: 128461..128916 (+)
• Length: 152 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GE022_RS00760	123694..124485	-	792	WP_164405167.1	helix-turn-helix domain-containing protein	-
GE022_RS00765	124640..124810	+	171	WP_164405168.1	transcriptional regulator	-
GE022_RS00770	124962..125588	+	627	WP_164228310.1	Bro-N domain-containing protein	-
GE022_RS00775	125602..125844	+	243	WP_003045756.1	hypothetical protein	-
GE022_RS00780	126098..126280	+	183	WP_003045758.1	hypothetical protein	-
GE022_RS00785	126292..126624	+	333	WP_164405642.1	hypothetical protein	-
GE022_RS00790	126624..126815	+	192	WP_136047644.1	hypothetical protein	-
GE022_RS00795	126827..126991	+	165	WP_164228299.1	hypothetical protein	-
GE022_RS00800	127456..127818	+	363	WP_164228314.1	DUF1492 domain-containing protein	-
GE022_RS00805	127793..128170	+	378	WP_164405640.1	DUF1492 domain-containing protein	-
GE022_RS00810	128239..128421	+	183	WP_015647112.1	type II toxin-antitoxin system HicA family toxin	Toxin
GE022_RS00815	128461..128916	+	456	WP_093998740.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GE022_RS00820	129282..130541	-	1260	WP_164228317.1	tyrosine--tRNA ligase	-
GE022_RS00825	130648..132948	+	2301	WP_164405639.1	penicillin-binding protein PBP1B	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	117879..128916	11037

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (20-74)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6630.84 Da
• Isoelectric Point: 10.8207

>T157849 WP_015647112.1 NZ_CP053790:128239-128421 [Streptococcus canis]
MPMTQKEMVKLLTANGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Nucleotide

• Length: 183 bp

>T157849 NZ_CP069495:c1742708-1742283 [Kytococcus sedentarius]
GTGATCATCCTCGACACAAACGTGATCTCGGAGATCTTTCGACCCTTGCCCGAGCCACGCGTAGCGGACTGGCTCACGTC
CCTGGAGGGTGACGTAGCCATCACGTCCGTCACGCTCGCAGAACTGCTGGCAGGTTTGCGACGGTTGCCGGATGGTCGGC
GCAGAGATGCGCTGACCAGACGAATTGACGCGGCGCTCGCACCGTACAGGGGCGGCCGCGCTGTGTTGCCGTTCGATGAC
GTGGCCGCCGACCGCTATGCCGACGTGCTCGTGGCTCGAGAGCGCGCGGGAGTGCCGATCAGTACCGCCGACGCGCAGAT
CGCCGCGATCTGCCTGGCGCACGGAGCAACCTGCGCTACGCGCAATGTGAAGGACTTCCAGCACACCGGCGTAGAACTGG
TGGATCCGTGGAAGGTCGATGCGTGA

Antitoxin

Protein

• Length: 152 a.a.
• Molecular weight: 17065.12 Da
• Isoelectric Point: 4.0258

>AT157849 WP_093998740.1 NZ_CP053790:128461-128916 [Streptococcus canis]
MLVTYPALFYYDDTQGETVAPYFVTFPDFEYSATQGEDMADAMAMASEWLGINLADYIENGRDIPKPSDINSLSLVDNNP
FREDKDFRLTYDPNKSFISLVMVDVSEYLGSQEPIKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Nucleotide

• Length: 456 bp

>AT157849 NZ_CP069495:c1742938-1742705 [Kytococcus sedentarius]
ATGTCATCCATCATCGTTCGCGGTCTCGACGACGCCGTGAAGCAGCAACTCGCCGCACAGGCGAAGGAGCACGGTCGGTC
GATGGAAGCCGAAGTTCGCGCCATCCTGACCAAAGCTGCACGCCGGCCGCACATAGGAATCGCTCTGCTGGCAGCCGCGC
AGGATGTCGGGGGAGTCGAGGAGCTACCGATCCCGGTGCGCGATGACGTCGCGCGGGCGGTGGACTTCGAGTGA

Structures

Toxin

• AlphaFold DB: V6Z2K9