157848

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1130016..1131448 Replicon chromosome
Accession NZ_CP053789
Organism Streptococcus canis strain HL_98_2

Toxin (Protein)


Gene name abiEi Uniprot ID Q8DZ35
Locus tag GE023_RS05665 Protein ID WP_001030302.1
Coordinates 1130603..1131448 (+) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID Q8DZ36
Locus tag GE023_RS05660 Protein ID WP_000037239.1
Coordinates 1130016..1130606 (+) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE023_RS05660 1130016..1130606 + 591 WP_000037239.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
GE023_RS05665 1130603..1131448 + 846 WP_001030302.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
GE023_RS05670 1131534..1134335 - 2802 WP_164406254.1 CHAP domain-containing protein -
GE023_RS05675 1134337..1135356 - 1020 WP_093998679.1 type IV secretion system protein VirB4 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1017277..1194004 176727


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-257)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32414.90 Da        Isoelectric Point: 5.2111

>T157848 WP_001030302.1 NZ_CP053789:1130603-1131448 [Streptococcus canis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITTIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKKDIDFNQLKNACQRTFSYRETELDFEKIIELLERFKSDP
TQNQQWQNYSKKYSYTKGISLANVLDEMISLITIIISTDSD

Download         Length: 846 bp

>T157848 NZ_CP069495:58018-58410 [Kytococcus sedentarius]
GTGATCGTCGACTCCTCGGCCATCGTGGCCATCCTGTTGGCAGAGCCGGAGCGCCAGGTCCTCCTCGAGGCCATCCAGCA
GGCCCCGAAGGTCGCGATGACTGCGGCCTCGTACCTCGAGGTGGGCATGGTGGTGGATGGGCGGGGAAACCCGGTCCTCT
CTCGCCAGTACGACGCCCTGTTGGAGGCCCTCGGCATCGAGGTGGTGGACACCACGGCCGAGCAGGCTCGTGTCGCCCGG
GCGGCGCACCGGGACTTCGGCCGGGGGAGTGGGCACCCGGCGCGCCTGAACTTCGGGGACTGCCTCAGTTACGCCGCCGC
CGTCCAGGATGGGGTCCCCTTGTTGTTCAAGGGTGACGACTTCATCCACACGGACGTCACGCCTGCCCTCTGA

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23074.63 Da        Isoelectric Point: 7.8056

>AT157848 WP_000037239.1 NZ_CP053789:1130016-1130606 [Streptococcus canis]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPMGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI

Download         Length: 591 bp

>AT157848 NZ_CP069495:57773-58021 [Kytococcus sedentarius]
ATGGCACTCACGATCAAGAACGACAGGGTGTGCGACCTGGCCCGCGAGGCGGCGCAGCGCTCGGGACAGTCTCAGGTGTC
CGTCATCGAGCAGGCGTTGGAGCGATACCTGGCCGACCATGCCGAGCCCGTGGGGCGGCGCGTGGACGAGGTGCTCGCCC
GCATCGACGCGAGCCTTGCCCCGGGGGATGCTGCCGCGATGCGCGTCGAGCTCGATCGCCTCTACGACGAACGGGGGCTC
CCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A8D822

Antitoxin

Source ID Structure
AlphaFold DB A0A2I7ZET8

References