Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 993004..993616 Replicon chromosome
Accession NZ_CP053789
Organism Streptococcus canis strain HL_98_2

Toxin (Protein)


Gene name parE Uniprot ID A0A4V0C1F2
Locus tag GE023_RS04890 Protein ID WP_003048651.1
Coordinates 993004..993339 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Q8EDD0
Locus tag GE023_RS04895 Protein ID WP_017648215.1
Coordinates 993329..993616 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE023_RS04865 988457..988816 - 360 WP_159305042.1 dihydroneopterin aldolase -
GE023_RS04870 988823..989623 - 801 WP_159305916.1 dihydropteroate synthase -
GE023_RS04875 989632..990198 - 567 WP_003048647.1 GTP cyclohydrolase I FolE -
GE023_RS04880 990230..991498 - 1269 WP_159305917.1 bifunctional folylpolyglutamate synthase/dihydrofolate synthase -
GE023_RS04885 991589..992449 - 861 Protein_903 homoserine kinase -
GE023_RS04890 993004..993339 - 336 WP_003048651.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GE023_RS04895 993329..993616 - 288 WP_017648215.1 hypothetical protein Antitoxin
GE023_RS04900 993793..994235 - 443 Protein_906 hypothetical protein -
GE023_RS04905 994421..995389 + 969 WP_003048658.1 polysaccharide deacetylase family protein -
GE023_RS04910 995496..996731 - 1236 WP_159305918.1 D-alanyl-D-alanine carboxypeptidase PBP3 -
GE023_RS04915 997049..998254 - 1206 WP_159305048.1 30S ribosomal protein S1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13215.04 Da        Isoelectric Point: 6.2385

>T157847 WP_003048651.1 NZ_CP053789:c993339-993004 [Streptococcus canis]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLKVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPARSDYIKLFK

Download         Length: 336 bp

>T157847 NZ_CP069488:4895036-4895563 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10949.53 Da        Isoelectric Point: 4.7271

>AT157847 WP_017648215.1 NZ_CP053789:c993616-993329 [Streptococcus canis]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT157847 NZ_CP069488:4894763-4895029 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V0C1F2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8EDD0

References