Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 120175..120852 Replicon chromosome
Accession NZ_CP053789
Organism Streptococcus canis strain HL_98_2

Toxin (Protein)


Gene name hicA Uniprot ID V6Z2K9
Locus tag GE023_RS00790 Protein ID WP_015647112.1
Coordinates 120175..120357 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GE023_RS00795 Protein ID WP_093998740.1
Coordinates 120397..120852 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE023_RS00750 115674..116501 - 828 WP_159305260.1 EbhA -
GE023_RS00755 116875..117522 - 648 WP_011529101.1 helix-turn-helix transcriptional regulator -
GE023_RS00760 117689..117886 + 198 WP_159305949.1 helix-turn-helix transcriptional regulator -
GE023_RS00765 117900..118508 + 609 WP_159305950.1 Bro-N domain-containing protein -
GE023_RS00770 118528..118935 + 408 WP_002992501.1 hypothetical protein -
GE023_RS00775 118949..119191 + 243 WP_003045756.1 hypothetical protein -
GE023_RS00780 119444..119626 + 183 WP_159305264.1 hypothetical protein -
GE023_RS00785 119638..119970 + 333 Protein_106 hypothetical protein -
GE023_RS00790 120175..120357 + 183 WP_015647112.1 type II toxin-antitoxin system HicA family toxin Toxin
GE023_RS00795 120397..120852 + 456 WP_093998740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GE023_RS00800 121218..122477 - 1260 WP_159305951.1 tyrosine--tRNA ligase -
GE023_RS00805 122584..124884 + 2301 WP_164401541.1 penicillin-binding protein PBP1B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 104811..120852 16041


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(20-74)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6630.84 Da        Isoelectric Point: 10.8207

>T157846 WP_015647112.1 NZ_CP053789:120175-120357 [Streptococcus canis]
MPMTQKEMVKLLTANGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T157846 NZ_CP069488:4792538-4792645 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 17065.12 Da        Isoelectric Point: 4.0258

>AT157846 WP_093998740.1 NZ_CP053789:120397-120852 [Streptococcus canis]
MLVTYPALFYYDDTQGETVAPYFVTFPDFEYSATQGEDMADAMAMASEWLGINLADYIENGRDIPKPSDINSLSLVDNNP
FREDKDFRLTYDPNKSFISLVMVDVSEYLGSQEPIKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 456 bp

>AT157846 NZ_CP069488:c4792481-4792424 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6Z2K9

Antitoxin

Source ID Structure

References