Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4335360..4336404 Replicon chromosome
Accession NZ_CP053785
Organism Escherichia coli isolate 2-101

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag HQN80_RS20940 Protein ID WP_000019186.1
Coordinates 4335360..4335908 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag HQN80_RS20945 Protein ID WP_000287252.1
Coordinates 4335931..4336404 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQN80_RS20900 4330532..4330711 - 180 WP_001341559.1 DUF4222 domain-containing protein -
HQN80_RS20905 4330749..4331123 - 375 Protein_4087 hypothetical protein -
HQN80_RS20910 4331167..4331367 - 201 WP_000649477.1 helix-turn-helix domain-containing protein -
HQN80_RS20915 4331458..4332132 + 675 WP_000859462.1 LexA family transcriptional repressor -
HQN80_RS20920 4332799..4333161 + 363 WP_000135682.1 hypothetical protein -
HQN80_RS20925 4333227..4334051 + 825 WP_001753751.1 DUF2303 family protein -
HQN80_RS20930 4334268..4335020 + 753 WP_001701368.1 hypothetical protein -
HQN80_RS20935 4335057..4335326 + 270 WP_001093912.1 pyocin activator PrtN family protein -
HQN80_RS20940 4335360..4335908 - 549 WP_000019186.1 hypothetical protein Toxin
HQN80_RS20945 4335931..4336404 - 474 WP_000287252.1 SocA family protein Antitoxin
HQN80_RS20950 4336691..4336813 - 123 WP_001300034.1 hypothetical protein -
HQN80_RS20955 4337176..4338192 - 1017 WP_000912595.1 DUF2713 family protein -
HQN80_RS20960 4338510..4339025 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
HQN80_RS20965 4339067..4339276 - 210 WP_001030593.1 CsbD family protein -
HQN80_RS20970 4339392..4340717 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
HQN80_RS20975 4340790..4341398 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4306160..4341398 35238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T157814 WP_000019186.1 NZ_CP053785:c4335908-4335360 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

>T157814 NZ_CP069480:c4613126-4612752 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT157814 WP_000287252.1 NZ_CP053785:c4336404-4335931 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT157814 NZ_CP069480:c4613583-4613215 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References