Detailed information of TA system TA157792

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3076266..3076929
• Replicon: chromosome
• Accession: NZ_CP053781
• Organism: Edwardsiella ictaluri strain 2234

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: C5BAS3
• Locus tag: F8538_RS14295
• Protein ID: WP_015872556.1
• Coordinates: 3076266..3076682 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: C5BAS4
• Locus tag: F8538_RS14300
• Protein ID: WP_015872557.1
• Coordinates: 3076663..3076929 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F8538_RS14275	3072189..3073922	-	1734	WP_081166575.1	single-stranded-DNA-specific exonuclease RecJ	-
F8538_RS14280	3073927..3074643	-	717	WP_081166578.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
F8538_RS14285	3074671..3075570	-	900	WP_081166581.1	site-specific tyrosine recombinase XerD	-
F8538_RS14290	3075729..3076241	+	513	WP_015872555.1	flavodoxin FldB	-
F8538_RS14295	3076266..3076682	-	417	WP_015872556.1	protein YgfX	Toxin
F8538_RS14300	3076663..3076929	-	267	WP_015872557.1	FAD assembly factor SdhE	Antitoxin
F8538_RS14305	3077283..3078278	+	996	WP_015872558.1	tRNA-modifying protein YgfZ	-
F8538_RS14310	3078319..3079143	-	825	WP_081166585.1	shikimate 5-dehydrogenase	-
F8538_RS14315	3079305..3080177	-	873	WP_015872560.1	nucleoside-specific channel-forming protein Tsx	-
F8538_RS14320	3080786..3081436	+	651	WP_035609190.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16145.89 Da
• Isoelectric Point: 11.3233

>T157792 WP_015872556.1 NZ_CP053781:c3076682-3076266 [Edwardsiella ictaluri]
VALWRCNVHASWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRLIARNSGELQRLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGTPCRRRLWLAADSMSREEWGQLRRALLDTGDDRV

Nucleotide

• Length: 417 bp

>T157792 NZ_CP069473:1404314-1404676 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10364.92 Da
• Isoelectric Point: 5.6951

>AT157792 WP_015872557.1 NZ_CP053781:c3076929-3076663 [Edwardsiella ictaluri]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLSCDDPELFKWLMNQGKPDDTDLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT157792 NZ_CP069473:1404147-1404317 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Structures

Toxin

• AlphaFold DB: C5BAS3

Antitoxin

• AlphaFold DB: C5BAS4