Detailed information of TA system TA157791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1006275..1006867
• Replicon: chromosome
• Accession: NZ_CP053781
• Organism: Edwardsiella ictaluri strain 2234

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: D0ZEC2
• Locus tag: F8538_RS04605
• Protein ID: WP_012847872.1
• Coordinates: 1006275..1006478 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: F8538_RS04610
• Protein ID: WP_081168012.1
• Coordinates: 1006499..1006867 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F8538_RS04565	1001495..1001956	+	462	WP_015870480.1	Lrp/AsnC family transcriptional regulator	-
F8538_RS04570	1001985..1002200	-	216	WP_128574010.1	hypothetical protein	-
F8538_RS04575	1002255..1002593	+	339	WP_015870482.1	P-II family nitrogen regulator	-
F8538_RS04580	1002615..1003895	+	1281	WP_049640187.1	ammonium transporter AmtB	-
F8538_RS04585	1003929..1004795	-	867	WP_015870484.1	acyl-CoA thioesterase II	-
F8538_RS04590	1004841..1005170	-	330	WP_015870485.1	MGMT family protein	-
F8538_RS04600	1006148..1006255	+	108	Protein_882	IS5/IS1182 family transposase	-
F8538_RS04605	1006275..1006478	-	204	WP_012847872.1	hemolysin expression modulator Hha	Toxin
F8538_RS04610	1006499..1006867	-	369	WP_081168012.1	Hha toxicity modulator TomB	Antitoxin
F8538_RS04615	1007227..1010379	-	3153	WP_015870488.1	multidrug efflux RND transporter permease subunit	-
F8538_RS04620	1010423..1011607	-	1185	WP_081168015.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-115)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8103.37 Da
• Isoelectric Point: 5.0914

>T157791 WP_012847872.1 NZ_CP053781:c1006478-1006275 [Edwardsiella ictaluri]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Nucleotide

• Length: 204 bp

>T157791 NZ_CP069473:1393264-1393473 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14259.02 Da
• Isoelectric Point: 5.4786

>AT157791 WP_081168012.1 NZ_CP053781:c1006867-1006499 [Edwardsiella ictaluri]
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALKQWLRTKRRMAYCLAHEKRNAALHV

Nucleotide

• Length: 369 bp

>AT157791 NZ_CP069473:1392964-1393257 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Structures

Toxin

• AlphaFold DB: A0A034SMG4