Detailed information of TA system TA157790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 264480..265002
• Replicon: plasmid pvirulence_VBP3636
• Accession: NZ_CP053772
• Organism: Klebsiella pneumoniae strain BP3636

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: A0A0C7KG00
• Locus tag: HBJ33_RS27205
• Protein ID: WP_038991638.1
• Coordinates: 264718..265002 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: -
• Locus tag: HBJ33_RS27200
• Protein ID: WP_179108528.1
• Coordinates: 264480..264728 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBJ33_RS27180	259689..260510	-	822	WP_004181772.1	hypothetical protein	-
HBJ33_RS27185	260572..260925	-	354	WP_004181774.1	hypothetical protein	-
HBJ33_RS27190	261070..262056	-	987	WP_040120328.1	hypothetical protein	-
HBJ33_RS27195	262390..264189	-	1800	WP_043907032.1	ATP-dependent helicase	-
HBJ33_RS27200	264480..264728	+	249	WP_179108528.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HBJ33_RS27205	264718..265002	+	285	WP_038991638.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HBJ33_RS27210	265019..265120	-	102	Protein_295	IS200/IS605 family transposase	-
HBJ33_RS27215	265156..266382	+	1227	WP_040120327.1	transposase	-
HBJ33_RS27220	266654..266878	-	225	Protein_297	transposase	-
HBJ33_RS27225	266957..267385	-	429	WP_077256229.1	IS200/IS605 family transposase	-
HBJ33_RS27230	267421..268608	+	1188	WP_043907031.1	transposase	-
HBJ33_RS27235	268707..269802	-	1096	Protein_300	conjugal transfer protein TraG N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaCTX-M-15 / blaTEM-1A / tet(D) / dfrA14 / blaOXA-1 / aac(6')-Ib-cr / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12	rmpA / iutA / iucD / iucC / iucB / iucA	1..317680	317680

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10993.73 Da
• Isoelectric Point: 10.6516

>T157790 WP_038991638.1 NZ_CP053772:264718-265002 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Nucleotide

• Length: 285 bp

>T157790 NZ_CP069470:2014364-2014552 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8899.09 Da
• Isoelectric Point: 3.8209

>AT157790 WP_179108528.1 NZ_CP053772:264480-264728 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERSGEAVIEVSLD
DL

Nucleotide

• Length: 249 bp

>AT157790 NZ_CP069470:2014075-2014335 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0C7KG00