Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 192994..193904 Replicon plasmid pvirulence_VBP3636
Accession NZ_CP053772
Organism Klebsiella pneumoniae strain BP3636

Toxin (Protein)


Gene name - Uniprot ID A0A5Q9LR54
Locus tag HBJ33_RS26820 Protein ID WP_004181896.1
Coordinates 192994..193464 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag HBJ33_RS26825 Protein ID WP_004181895.1
Coordinates 193461..193904 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ33_RS26795 188490..188867 + 378 WP_004181901.1 hypothetical protein -
HBJ33_RS26800 189065..190039 - 975 WP_043907013.1 hypothetical protein -
HBJ33_RS26805 190642..190800 - 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
HBJ33_RS26810 190872..192053 + 1182 WP_004883380.1 IS481 family transposase -
HBJ33_RS26815 192624..192884 + 261 WP_004026352.1 hypothetical protein -
HBJ33_RS26820 192994..193464 - 471 WP_004181896.1 RES family NAD+ phosphorylase Toxin
HBJ33_RS26825 193461..193904 - 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
HBJ33_RS26830 194005..195276 - 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
HBJ33_RS26835 195276..195698 - 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
HBJ33_RS26840 195784..197271 - 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-15 / blaTEM-1A / tet(D) / dfrA14 / blaOXA-1 / aac(6')-Ib-cr / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 rmpA / iutA / iucD / iucC / iucB / iucA 1..317680 317680
- flank IS/Tn - - 190872..192053 1181


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17549.81 Da        Isoelectric Point: 4.6155

>T157789 WP_004181896.1 NZ_CP053772:c193464-192994 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T157789 NZ_CP069470:c967997-967902 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT157789 WP_004181895.1 NZ_CP053772:c193904-193461 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT157789 NZ_CP069470:967815-967874 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LR54

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References