Detailed information of TA system TA157778

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3964143..3964800
• Replicon: chromosome
• Accession: NZ_CP053771
• Organism: Klebsiella pneumoniae strain BP3636

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HBJ33_RS18995
• Protein ID: WP_004181233.1
• Coordinates: 3964390..3964800 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: HBJ33_RS18990
• Protein ID: WP_002916312.1
• Coordinates: 3964143..3964409 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBJ33_RS18965	3959299..3960732	-	1434	WP_004181234.1	6-phospho-beta-glucosidase	-
HBJ33_RS18970	3960851..3961579	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
HBJ33_RS18975	3961629..3961940	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
HBJ33_RS18980	3962104..3962763	+	660	WP_002916317.1	hemolysin III family protein	-
HBJ33_RS18985	3962914..3963897	-	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
HBJ33_RS18990	3964143..3964409	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
HBJ33_RS18995	3964390..3964800	+	411	WP_004181233.1	protein YgfX	Toxin
HBJ33_RS19000	3964807..3965328	-	522	WP_004144730.1	flavodoxin FldB	-
HBJ33_RS19005	3965429..3966325	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
HBJ33_RS19010	3966348..3967061	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HBJ33_RS19015	3967067..3968800	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.92 Da
• Isoelectric Point: 11.1565

>T157778 WP_004181233.1 NZ_CP053771:3964390-3964800 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T157778 NZ_CP069461:7829-8215 [Escherichia coli]
ATGAAATTCGTTAGTTCACAGGAAGTGATTGAGTTTCATGACCGCTTGATTTCGCGTGATGGTGGCGTGGCGGGTATGCC
AGAACCCGGTCGCGCTGACGCGATCATTCATCGTGTTTTGAACATGTATCATTATGAAGGTGTGACAGATATTATGGATC
TGGCTGCCGTGTATTTAGTTGCTATTGCTCGTGGTCACATTTTCAACGATGCAAATAAGCGAACAGCCTTGTTTGTTGCA
CAGGTTTTTTTAAAACGGAATGGTGTACATATTATTAGTTCACGTATTTCGTTTGATGAAATGCAAATTATCGCTTTGAA
TGCTGCAACAGGAGAATATAACTGGAAGATGGTTTCTGACCATCTTAAAGCCATTATTCTAAATTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT157778 WP_002916312.1 NZ_CP053771:3964143-3964409 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT157778 NZ_CP069461:7608-7832 [Escherichia coli]
ATGTTTACATGTAACTATAGCCATGCTCGCGATAACCTGGCCTCGTTGCTCGAGCTGGCGGTTGATGAAAATCAGCCTGT
TGAGATTCAGCGCCGTAAAGGTGGCGCGGCTGTACTAGTTGATAAAGACGCTTTTGAACGATACCGTAAAGCGGCTCTTG
ATGCTGAGTTTGCTGAGATCATGCAAAGTCATGGGACGGCCTATACGGAGCTTTCTAAGCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41