Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1880433..1881052 Replicon chromosome
Accession NZ_CP053771
Organism Klebsiella pneumoniae strain BP3636

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HBJ33_RS09045 Protein ID WP_002892050.1
Coordinates 1880834..1881052 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HBJ33_RS09040 Protein ID WP_002892066.1
Coordinates 1880433..1880807 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ33_RS09030 1875585..1876778 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HBJ33_RS09035 1876801..1879947 + 3147 WP_179108445.1 multidrug efflux RND transporter permease subunit AcrB -
HBJ33_RS09040 1880433..1880807 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HBJ33_RS09045 1880834..1881052 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HBJ33_RS09050 1881211..1881777 + 567 WP_002892030.1 maltose O-acetyltransferase -
HBJ33_RS09055 1881749..1881889 - 141 WP_004147370.1 hypothetical protein -
HBJ33_RS09060 1881910..1882380 + 471 WP_002892026.1 YlaC family protein -
HBJ33_RS09065 1882355..1883806 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HBJ33_RS09070 1883907..1884605 + 699 WP_004178762.1 GNAT family N-acetyltransferase -
HBJ33_RS09075 1884602..1884742 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HBJ33_RS09080 1884742..1885005 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T157772 WP_002892050.1 NZ_CP053771:1880834-1881052 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T157772 NZ_CP069459:4228194-4228490 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT157772 WP_002892066.1 NZ_CP053771:1880433-1880807 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT157772 NZ_CP069459:4228492-4228887 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References