157764

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 228738..229260 Replicon plasmid pvirulence_VBA10835
Accession NZ_CP053766
Organism Klebsiella pneumoniae strain BA10835

Toxin (Protein)


Gene name stbE Uniprot ID A0A0C7KG00
Locus tag HBJ44_RS26985 Protein ID WP_038991638.1
Coordinates 228976..229260 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag HBJ44_RS26980 Protein ID WP_004181777.1
Coordinates 228738..228986 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ44_RS26960 223947..224768 - 822 WP_004181772.1 hypothetical protein -
HBJ44_RS26965 224830..225183 - 354 WP_004181774.1 hypothetical protein -
HBJ44_RS26970 225328..226314 - 987 WP_040120328.1 hypothetical protein -
HBJ44_RS26975 226648..228447 - 1800 WP_043907032.1 ATP-dependent helicase -
HBJ44_RS26980 228738..228986 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HBJ44_RS26985 228976..229260 + 285 WP_038991638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HBJ44_RS26990 229277..229378 - 102 Protein_251 IS200/IS605 family transposase -
HBJ44_RS26995 229414..230640 + 1227 WP_166689928.1 transposase -
HBJ44_RS27000 230912..231136 - 225 Protein_253 transposase -
HBJ44_RS27005 231215..231643 - 429 WP_077256229.1 IS200/IS605 family transposase -
HBJ44_RS27010 231679..232866 + 1188 WP_043907031.1 transposase -
HBJ44_RS27015 232965..234060 - 1096 Protein_256 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-15 / blaTEM-1B / tet(D) / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 iucA / iucB / iucC / iucD / iutA / rmpA 1..307718 307718


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10993.73 Da        Isoelectric Point: 10.6516

>T157764 WP_038991638.1 NZ_CP053766:228976-229260 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Download         Length: 285 bp

>T157764 NZ_CP069459:1315090-1315197 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT157764 WP_004181777.1 NZ_CP053766:228738-228986 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT157764 NZ_CP069459:c1315043-1314977 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7KG00

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References