157763

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 169309..170060 Replicon plasmid pvirulence_VBA10835
Accession NZ_CP053766
Organism Klebsiella pneumoniae strain BA10835

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag HBJ44_RS26655 Protein ID WP_048333033.1
Coordinates 169309..169791 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag HBJ44_RS26660 Protein ID WP_004902250.1
Coordinates 169782..170060 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ44_RS26635 165708..166355 - 648 WP_014386537.1 EcsC family protein -
HBJ44_RS26640 166382..167137 - 756 WP_004902235.1 DUF2971 domain-containing protein -
HBJ44_RS26645 167238..167630 - 393 WP_032442757.1 hypothetical protein -
HBJ44_RS26650 167735..168274 - 540 WP_004902239.1 hypothetical protein -
HBJ44_RS26655 169309..169791 - 483 WP_048333033.1 GNAT family N-acetyltransferase Toxin
HBJ44_RS26660 169782..170060 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
HBJ44_RS26665 170182..170394 - 213 WP_016946198.1 hypothetical protein -
HBJ44_RS26670 170502..170843 - 342 WP_032437747.1 hypothetical protein -
HBJ44_RS26675 171674..172132 - 459 WP_014386535.1 hypothetical protein -
HBJ44_RS26680 172785..173240 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
HBJ44_RS26685 173312..173677 + 366 WP_004200999.1 mercuric ion transporter MerT -
HBJ44_RS26690 173693..173968 + 276 WP_043907009.1 mercury resistance system periplasmic binding protein MerP -
HBJ44_RS26695 173996..174421 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-15 / blaTEM-1B / tet(D) / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 iucA / iucB / iucC / iucD / iutA / rmpA 1..307718 307718


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17708.53 Da        Isoelectric Point: 8.9130

>T157763 WP_048333033.1 NZ_CP053766:c169791-169309 [Klebsiella pneumoniae]
MGMRAPESLMSEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T157763 NZ_CP069459:1314555-1314662 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT157763 WP_004902250.1 NZ_CP053766:c170060-169782 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT157763 NZ_CP069459:c1314508-1314442 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References