157756

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4089540..4090159 Replicon chromosome
Accession NZ_CP053765
Organism Klebsiella pneumoniae strain BA10835

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HBJ44_RS19790 Protein ID WP_002892050.1
Coordinates 4089941..4090159 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HBJ44_RS19785 Protein ID WP_002892066.1
Coordinates 4089540..4089914 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ44_RS19775 4084692..4085885 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HBJ44_RS19780 4085908..4089054 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HBJ44_RS19785 4089540..4089914 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HBJ44_RS19790 4089941..4090159 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HBJ44_RS19795 4090318..4090884 + 567 WP_002892030.1 maltose O-acetyltransferase -
HBJ44_RS19800 4090856..4090996 - 141 WP_004147370.1 hypothetical protein -
HBJ44_RS19805 4091017..4091487 + 471 WP_002892026.1 YlaC family protein -
HBJ44_RS19810 4091462..4092913 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HBJ44_RS19815 4093014..4093712 + 699 WP_004178762.1 GNAT family N-acetyltransferase -
HBJ44_RS19820 4093709..4093849 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HBJ44_RS19825 4093849..4094112 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T157756 WP_002892050.1 NZ_CP053765:4089941-4090159 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T157756 NZ_CP069456:4125-4283 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT157756 WP_002892066.1 NZ_CP053765:4089540-4089914 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT157756 NZ_CP069456:4014-4079 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References