Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 816355..817012 Replicon chromosome
Accession NZ_CP053765
Organism Klebsiella pneumoniae strain BA10835

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HBJ44_RS04010 Protein ID WP_004181233.1
Coordinates 816602..817012 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HBJ44_RS04005 Protein ID WP_002916312.1
Coordinates 816355..816621 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ44_RS03980 811511..812944 - 1434 WP_004181234.1 6-phospho-beta-glucosidase -
HBJ44_RS03985 813063..813791 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HBJ44_RS03990 813841..814152 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HBJ44_RS03995 814316..814975 + 660 WP_002916317.1 hemolysin III family protein -
HBJ44_RS04000 815126..816109 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HBJ44_RS04005 816355..816621 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HBJ44_RS04010 816602..817012 + 411 WP_004181233.1 protein YgfX Toxin
HBJ44_RS04015 817019..817540 - 522 WP_004144730.1 flavodoxin FldB -
HBJ44_RS04020 817641..818537 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HBJ44_RS04025 818560..819273 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HBJ44_RS04030 819279..821012 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16121.92 Da        Isoelectric Point: 11.1565

>T157745 WP_004181233.1 NZ_CP053765:816602-817012 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T157745 NZ_CP069453:c3652543-3652436 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT157745 WP_002916312.1 NZ_CP053765:816355-816621 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT157745 NZ_CP069453:3652599-3652660 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References