157727

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4170532..4171186 Replicon chromosome
Accession NZ_CP053751
Organism Shigella sonnei strain 506

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag COO90_RS20935 Protein ID WP_000244777.1
Coordinates 4170532..4170939 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag COO90_RS20940 Protein ID WP_000354046.1
Coordinates 4170920..4171186 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COO90_RS20915 (4166489) 4166489..4168222 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
COO90_RS20920 (4168228) 4168228..4168938 - 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
COO90_RS20925 (4168963) 4168963..4169859 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
COO90_RS20930 (4169971) 4169971..4170492 + 522 WP_001055874.1 flavodoxin FldB -
COO90_RS20935 (4170532) 4170532..4170939 - 408 WP_000244777.1 protein YgfX Toxin
COO90_RS20940 (4170920) 4170920..4171186 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
COO90_RS20945 (4171429) 4171429..4172409 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
COO90_RS20950 (4172605) 4172605..4173264 - 660 WP_000250274.1 hemolysin III family protein -
COO90_RS20955 (4173428) 4173428..4173739 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
COO90_RS20960 (4173784) 4173784..4175217 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
COO90_RS20965 (4175274) 4175274..4176017 - 744 WP_000951937.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T157727 WP_000244777.1 NZ_CP053751:c4170939-4170532 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T157727 NZ_CP069451:c4013630-4013295 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGA
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT157727 WP_000354046.1 NZ_CP053751:c4171186-4170920 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT157727 NZ_CP069451:c4013878-4013630 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References