Detailed information of TA system TA157723

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 2614038..2614522
• Replicon: chromosome
• Accession: NZ_CP053751
• Organism: Shigella sonnei strain 506

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A377EAU1
• Locus tag: COO90_RS12960
• Protein ID: WP_014334020.1
• Coordinates: 2614038..2614328 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: A0A376K4R9
• Locus tag: COO90_RS12965
• Protein ID: WP_005142544.1
• Coordinates: 2614328..2614522 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
COO90_RS12925 (2609109)	2609109..2609723	-	615	WP_000148710.1	Tat proofreading chaperone DmsD	-
COO90_RS12930 (2609766)	2609766..2610620	-	855	WP_000526502.1	dimethyl sulfoxide reductase anchor subunit family protein	-
COO90_RS12935 (2610622)	2610622..2611239	-	618	WP_000213029.1	dimethylsulfoxide reductase subunit B	-
COO90_RS12940 (2611250)	2611250..2612326	-	1077	Protein_2519	molybdopterin dinucleotide binding domain-containing protein	-
COO90_RS12945 (2612384)	2612384..2613081	+	698	WP_094096600.1	IS1-like element IS1A family transposase	-
COO90_RS12950 (2613229)	2613229..2613594	-	366	WP_024174355.1	hypothetical protein	-
COO90_RS12955 (2613606)	2613606..2613758	-	153	WP_000379558.1	DUF1391 family protein	-
COO90_RS12960 (2614038)	2614038..2614328	-	291	WP_014334020.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
COO90_RS12965 (2614328)	2614328..2614522	-	195	WP_005142544.1	hypothetical protein	Antitoxin
COO90_RS12970 (2614542)	2614542..2615027	-	486	WP_053002468.1	helix-turn-helix domain-containing protein	-
COO90_RS12975 (2615154)	2615154..2615417	+	264	WP_001048456.1	helix-turn-helix transcriptional regulator	-
COO90_RS12980 (2615414)	2615414..2615839	+	426	WP_000693826.1	toxin YdaT family protein	-
COO90_RS12985 (2615911)	2615911..2616975	+	1065	WP_039063478.1	phage replisome organizer	-
COO90_RS12990 (2616982)	2616982..2617728	+	747	WP_000788740.1	ATP-binding protein	-
COO90_RS12995 (2617750)	2617750..2618475	+	726	WP_000450631.1	DUF1627 domain-containing protein	-
COO90_RS13000 (2618491)	2618491..2618913	+	423	WP_001151171.1	DUF977 family protein	-
COO90_RS13005 (2618971)	2618971..2619327	+	357	WP_005140877.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2612757..2638349	25592

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11062.93 Da
• Isoelectric Point: 10.2013

>T157723 WP_014334020.1 NZ_CP053751:c2614328-2614038 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Nucleotide

• Length: 291 bp

>T157723 NZ_CP069451:c2885476-2885374 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7097.98 Da
• Isoelectric Point: 4.1759

>AT157723 WP_005142544.1 NZ_CP053751:c2614522-2614328 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Nucleotide

• Length: 195 bp

>AT157723 NZ_CP069451:2885336-2885604 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Structures

Toxin

• AlphaFold DB: A0A377EAU1

Antitoxin

• AlphaFold DB: A0A376K4R9