Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1437482..1438100 Replicon chromosome
Accession NZ_CP053751
Organism Shigella sonnei strain 506

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag COO90_RS06960 Protein ID WP_001291435.1
Coordinates 1437482..1437700 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag COO90_RS06965 Protein ID WP_000344804.1
Coordinates 1437726..1438100 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COO90_RS06925 (1432774) 1432774..1433346 + 573 WP_000779812.1 YbaY family lipoprotein -
COO90_RS06930 (1433377) 1433377..1433688 - 312 WP_000409911.1 MGMT family protein -
COO90_RS06940 (1434067) 1434067..1434420 + 354 WP_000878140.1 DUF1428 domain-containing protein -
COO90_RS06945 (1434462) 1434462..1436010 - 1549 Protein_1344 cyclic-guanylate-specific phosphodiesterase PdeB -
COO90_RS06950 (1436174) 1436174..1436644 - 471 WP_000136192.1 YlaC family protein -
COO90_RS06955 (1436760) 1436760..1437311 - 552 WP_000102564.1 maltose O-acetyltransferase -
COO90_RS06960 (1437482) 1437482..1437700 - 219 WP_001291435.1 HHA domain-containing protein Toxin
COO90_RS06965 (1437726) 1437726..1438100 - 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
COO90_RS06970 (1438646) 1438646..1441795 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
COO90_RS06975 (1441818) 1441818..1443011 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T157714 WP_001291435.1 NZ_CP053751:c1437700-1437482 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T157714 NZ_CP069451:c1032990-1032838 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT157714 WP_000344804.1 NZ_CP053751:c1438100-1437726 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT157714 NZ_CP069451:1033039-1033096 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References