Detailed information of TA system TA157709

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4485441..4486073
• Replicon: chromosome
• Accession: NZ_CP053750
• Organism: Chromobacterium sp. Beijing

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HQN78_RS20940
• Protein ID: WP_235085974.1
• Coordinates: 4485441..4485857 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2T5NW37
• Locus tag: HQN78_RS20945
• Protein ID: WP_019103136.1
• Coordinates: 4485861..4486073 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HQN78_RS20910 (HQN78_20680)	4480976..4481725	-	750	WP_048413068.1	sulfite exporter TauE/SafE family protein	-
HQN78_RS20915 (HQN78_20685)	4482034..4482375	+	342	WP_107800876.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
HQN78_RS20920 (HQN78_20690)	4482490..4483527	-	1038	WP_227105456.1	dihydroorotase	-
HQN78_RS20925 (HQN78_20695)	4483724..4483954	-	231	WP_235085971.1	sulfurtransferase TusA family protein	-
HQN78_RS20930 (HQN78_20700)	4484144..4484923	+	780	WP_107800874.1	NRDE family protein	-
HQN78_RS20935 (HQN78_20705)	4484938..4485435	+	498	WP_158274364.1	CNP1-like family protein	-
HQN78_RS20940 (HQN78_20710)	4485441..4485857	-	417	WP_235085974.1	type II toxin-antitoxin system VapC family toxin	Toxin
HQN78_RS20945 (HQN78_20715)	4485861..4486073	-	213	WP_019103136.1	hypothetical protein	Antitoxin
HQN78_RS20950 (HQN78_20720)	4486227..4489313	-	3087	WP_235085976.1	efflux RND transporter permease subunit	-
HQN78_RS20955 (HQN78_20725)	4489313..4490437	-	1125	WP_235085978.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15074.17 Da
• Isoelectric Point: 6.7174

>T157709 WP_235085974.1 NZ_CP053750:c4485857-4485441 [Chromobacterium sp. Beijing]
VYLVDTNIVSEARKGGKANAGVLAFWRSADTDSLYLSAISVGDIRRGIENLKHRGDLKQAGLLEQWLDTITQEFSQRILN
FDADCAQVWGKLMSPHPQNAVDKQIAAIALIHDLTIVTRNSGDFAGTGVKLLNPFAPI

Nucleotide

• Length: 417 bp

>T157709 NZ_CP069448:c107530-107225 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7840.84 Da
• Isoelectric Point: 6.4684

>AT157709 WP_019103136.1 NZ_CP053750:c4486073-4485861 [Chromobacterium sp. Beijing]
MANLIVRNIDDEVAAELKRRAAAHGVSAEAEHRRILRSALLAQPKRRSFAEVLANMPDVGEDADFERSRE

Nucleotide

• Length: 213 bp

>AT157709 NZ_CP069448:c107750-107532 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2T5NW37