Detailed information of TA system TA157707

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2490443..2491045
• Replicon: chromosome
• Accession: NZ_CP053750
• Organism: Chromobacterium sp. Beijing

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HQN78_RS11450
• Protein ID: WP_235089564.1
• Coordinates: 2490863..2491045 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HQN78_RS11445
• Protein ID: WP_107799897.1
• Coordinates: 2490443..2490853 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HQN78_RS11430 (HQN78_11315)	2486910..2487851	-	942	WP_235089561.1	GlxA family transcriptional regulator	-
HQN78_RS11435 (HQN78_11320)	2488172..2489317	+	1146	WP_235089562.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
HQN78_RS11440 (HQN78_11325)	2489333..2490271	+	939	WP_235089563.1	PDR/VanB family oxidoreductase	-
HQN78_RS11445 (HQN78_11330)	2490443..2490853	-	411	WP_107799897.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HQN78_RS11450 (HQN78_11335)	2490863..2491045	-	183	WP_235089564.1	type II toxin-antitoxin system HicA family toxin	Toxin
HQN78_RS11455 (HQN78_11340)	2491329..2492747	-	1419	WP_235089565.1	sigma 54-interacting transcriptional regulator	-
HQN78_RS11460 (HQN78_11345)	2493202..2493993	+	792	WP_235089566.1	ATP-binding cassette domain-containing protein	-
HQN78_RS11465 (HQN78_11350)	2494012..2494782	+	771	WP_235089568.1	transporter substrate-binding domain-containing protein	-
HQN78_RS11470 (HQN78_11355)	2494823..2495536	+	714	WP_205465673.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6608.71 Da
• Isoelectric Point: 10.4134

>T157707 WP_235089564.1 NZ_CP053750:c2491045-2490863 [Chromobacterium sp. Beijing]
VTSKEVISMIEADGWYLVAAKGSHQQFKHPIKTGWVTVPHPKKDIPIGTLNSIKKQAGLQ

Nucleotide

• Length: 183 bp

>T157707 NZ_CP069447:c4768137-4767964 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14877.89 Da
• Isoelectric Point: 4.6219

>AT157707 WP_107799897.1 NZ_CP053750:c2490853-2490443 [Chromobacterium sp. Beijing]
MYYPIAVEPGDDQHAYGVIVPDLPGCFSAGDTLDEAIRNAREAIELHLEGLVDDLDVIPLASSAQAHVGKPEFAGHLWAL
VDVDITRYLGKATKINVTLPANLLHRIDEYVASHPEYDSRSGFLAKTALEKLLCRP

Nucleotide

• Length: 411 bp

>AT157707 NZ_CP069447:c4768461-4768165 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG