Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2490443..2491045 Replicon chromosome
Accession NZ_CP053750
Organism Chromobacterium sp. Beijing

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HQN78_RS11450 Protein ID WP_235089564.1
Coordinates 2490863..2491045 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HQN78_RS11445 Protein ID WP_107799897.1
Coordinates 2490443..2490853 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQN78_RS11430 (HQN78_11315) 2486910..2487851 - 942 WP_235089561.1 GlxA family transcriptional regulator -
HQN78_RS11435 (HQN78_11320) 2488172..2489317 + 1146 WP_235089562.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
HQN78_RS11440 (HQN78_11325) 2489333..2490271 + 939 WP_235089563.1 PDR/VanB family oxidoreductase -
HQN78_RS11445 (HQN78_11330) 2490443..2490853 - 411 WP_107799897.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HQN78_RS11450 (HQN78_11335) 2490863..2491045 - 183 WP_235089564.1 type II toxin-antitoxin system HicA family toxin Toxin
HQN78_RS11455 (HQN78_11340) 2491329..2492747 - 1419 WP_235089565.1 sigma 54-interacting transcriptional regulator -
HQN78_RS11460 (HQN78_11345) 2493202..2493993 + 792 WP_235089566.1 ATP-binding cassette domain-containing protein -
HQN78_RS11465 (HQN78_11350) 2494012..2494782 + 771 WP_235089568.1 transporter substrate-binding domain-containing protein -
HQN78_RS11470 (HQN78_11355) 2494823..2495536 + 714 WP_205465673.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6608.71 Da        Isoelectric Point: 10.4134

>T157707 WP_235089564.1 NZ_CP053750:c2491045-2490863 [Chromobacterium sp. Beijing]
VTSKEVISMIEADGWYLVAAKGSHQQFKHPIKTGWVTVPHPKKDIPIGTLNSIKKQAGLQ

Download         Length: 183 bp

>T157707 NZ_CP069447:c4768137-4767964 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14877.89 Da        Isoelectric Point: 4.6219

>AT157707 WP_107799897.1 NZ_CP053750:c2490853-2490443 [Chromobacterium sp. Beijing]
MYYPIAVEPGDDQHAYGVIVPDLPGCFSAGDTLDEAIRNAREAIELHLEGLVDDLDVIPLASSAQAHVGKPEFAGHLWAL
VDVDITRYLGKATKINVTLPANLLHRIDEYVASHPEYDSRSGFLAKTALEKLLCRP

Download         Length: 411 bp

>AT157707 NZ_CP069447:c4768461-4768165 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References