Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2107022..2108468 Replicon chromosome
Accession NZ_CP053750
Organism Chromobacterium sp. Beijing

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HQN78_RS09770 Protein ID WP_235089242.1
Coordinates 2107022..2107657 (+) Length 212 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag HQN78_RS09775 Protein ID WP_235089244.1
Coordinates 2107650..2108468 (+) Length 273 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQN78_RS09745 (HQN78_09655) 2102351..2103496 + 1146 WP_235089239.1 elongation factor P maturation arginine rhamnosyltransferase EarP -
HQN78_RS09750 (HQN78_09660) 2103559..2104122 + 564 WP_048412240.1 elongation factor P -
HQN78_RS09755 (HQN78_09665) 2104212..2104646 - 435 Protein_1921 cupin domain-containing protein -
HQN78_RS09760 (HQN78_09670) 2105058..2105942 + 885 WP_199225854.1 hypothetical protein -
HQN78_RS09765 (HQN78_09675) 2105989..2106744 + 756 WP_235089240.1 SDR family oxidoreductase -
HQN78_RS09770 (HQN78_09680) 2107022..2107657 + 636 WP_235089242.1 alpha/beta fold hydrolase Toxin
HQN78_RS09775 (HQN78_09685) 2107650..2108468 + 819 WP_235089244.1 IclR family transcriptional regulator Antitoxin
HQN78_RS09780 (HQN78_09690) 2108481..2109281 + 801 WP_235089247.1 SDR family oxidoreductase -
HQN78_RS09785 (HQN78_09695) 2109271..2110935 + 1665 WP_235089248.1 thiamine pyrophosphate-binding protein -
HQN78_RS09790 2110940..2111392 + 453 WP_235089249.1 hypothetical protein -
HQN78_RS09795 2111389..2111769 + 381 WP_235089250.1 DUF108 domain-containing protein -
HQN78_RS09800 (HQN78_09705) 2111778..2113256 + 1479 WP_235089251.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(8-192)

Antitoxin

Transcription regulator IclR, C-terminal

(135-257)


Sequences

Toxin        


Download         Length: 212 a.a.        Molecular weight: 22141.18 Da        Isoelectric Point: 7.8018

>T157706 WP_235089242.1 NZ_CP053750:2107022-2107657 [Chromobacterium sp. Beijing]
MPQARPKADDYAQALEGFLKAAGVTRCALVGHSLGGLMAAAHARRHPQRLERLLLVSPAQGYGAADRRADGARIRGERLR
ALHAQGLAQVADQAPARLLSASADAAARAWVRWNMAQLKEDGYGQAVELLTGDDIARYAPSPLPVTVFCGERDLATPPAD
CQAVAAAFNAPFHLIPGCGHACHVEAPAALADLLSAALAPSHPHTKEAHHG

Download         Length: 636 bp

>T157706 NZ_CP069447:c4578529-4578152 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 273 a.a.        Molecular weight: 29607.10 Da        Isoelectric Point: 7.5498

>AT157706 WP_235089244.1 NZ_CP053750:2107650-2108468 [Chromobacterium sp. Beijing]
MDEQNLNDAAARYTVPALERGLRLLGEFSRGEPTLSAPELARRLALPRSTVFRMLATLEQLGFIERAEGGRDYRLGIAVL
RLGFEYLSSLELTELGLPVLGRLRDRIGHACSLVVRDGRSIVYVAKVNPPSWIASNINIGARLPAHATVFGRILLSELPL
EKLRELYPEEHLDIHSSQTPRNTLELFHLLQQDRERSCLVGEGFFETNISTVAAPVRNHGGAIIAAIGATLPMPRLEPGQ
ADALAGHIRAAAAELSRALGHAGGGMGKVIHL

Download         Length: 819 bp

>AT157706 NZ_CP069447:c4578987-4578619 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References