157703

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 3406542..3407195 Replicon chromosome
Accession NZ_CP053749
Organism Mycobacterium avium subsp. paratuberculosis S397

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MAPS_RS15880 Protein ID WP_003872880.1
Coordinates 3406542..3407003 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID Q742J1
Locus tag MAPS_RS15885 Protein ID WP_003872881.1
Coordinates 3407007..3407195 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAPS_RS15865 3403034..3403420 - 387 WP_003872877.1 hypothetical protein -
MAPS_RS15870 3403460..3405043 - 1584 WP_003872878.1 DUF4185 domain-containing protein -
MAPS_RS15875 3406039..3406473 - 435 WP_003872879.1 hypothetical protein -
MAPS_RS15880 3406542..3407003 - 462 WP_003872880.1 SRPBCC family protein Toxin
MAPS_RS15885 3407007..3407195 - 189 WP_003872881.1 antitoxin Antitoxin
MAPS_RS15890 3407258..3409630 - 2373 WP_003872882.1 HAD-IC family P-type ATPase -
MAPS_RS15895 3409627..3411213 - 1587 WP_003872883.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(2-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-51)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16626.19 Da        Isoelectric Point: 9.5654

>T157703 WP_003872880.1 NZ_CP053749:c3407003-3406542 [Mycobacterium avium subsp. paratuberculosis S397]
VAKLSGSIDVPLPPEVAWQHASDLSRYKEWLTIHRVWRSTLPDQIDKGTVVESIVEVKGMLNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPKADGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFARSDPSTNGHR

Download         Length: 462 bp

>T157703 NZ_CP069447:4429304-4429456 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6745.42 Da        Isoelectric Point: 4.4865

>AT157703 WP_003872881.1 NZ_CP053749:c3407195-3407007 [Mycobacterium avium subsp. paratuberculosis S397]
MGFLDKAKDLLSQNADKVEMAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKATGATETGDQQG

Download         Length: 189 bp

>AT157703 NZ_CP069447:c4429255-4429198 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2WC18

References