157702

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 2921964..2922628 Replicon chromosome
Accession NZ_CP053749
Organism Mycobacterium avium subsp. paratuberculosis S397

Toxin (Protein)


Gene name vapC Uniprot ID Q73YC9
Locus tag MAPS_RS13675 Protein ID WP_003872398.1
Coordinates 2921964..2922371 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q73YC8
Locus tag MAPS_RS13680 Protein ID WP_003872399.1
Coordinates 2922368..2922628 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAPS_RS13650 2917143..2918312 + 1170 WP_003872395.1 acyl-CoA dehydrogenase -
MAPS_RS13655 2918301..2918831 - 531 WP_003878213.1 TetR/AcrR family transcriptional regulator -
MAPS_RS13660 2918952..2919497 - 546 WP_003878214.1 carboxymuconolactone decarboxylase family protein -
MAPS_RS13665 2919494..2920015 - 522 WP_003878215.1 carboxymuconolactone decarboxylase family protein -
MAPS_RS13670 2920252..2921817 + 1566 WP_003872397.1 serine/threonine protein kinase -
MAPS_RS13675 2921964..2922371 - 408 WP_003872398.1 type II toxin-antitoxin system VapC family toxin Toxin
MAPS_RS13680 2922368..2922628 - 261 WP_003872399.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MAPS_RS13685 2922809..2923261 - 453 WP_003872400.1 VOC family protein -
MAPS_RS13690 2923427..2924695 + 1269 WP_003872401.1 cytochrome P450 -
MAPS_RS13695 2924897..2926354 - 1458 WP_003872402.1 serine/threonine protein kinase -
MAPS_RS13700 2926550..2927212 - 663 WP_003872403.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14418.47 Da        Isoelectric Point: 4.5642

>T157702 WP_003872398.1 NZ_CP053749:c2922371-2921964 [Mycobacterium avium subsp. paratuberculosis S397]
MTARPAAGVLDTSVFIASESGRQLDEARIPDEVATTVVTLAELHAGVLAATTSNVRAQRLATLESIADMEMLPVDDDAVR
MWARLRIHLAEAGRRMRANDLWIAAIAASRGLPVVTQDDDFAALDGAANLAIIRV

Download         Length: 408 bp

>T157702 NZ_CP069447:c4392369-4392055 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9635.01 Da        Isoelectric Point: 11.7137

>AT157702 WP_003872399.1 NZ_CP053749:c2922628-2922368 [Mycobacterium avium subsp. paratuberculosis S397]
MSEVASRELRNDTAGVLRRVREGEDVTITINGRAVAMLTPLRPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT157702 NZ_CP069447:c4392605-4392372 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L5MIC8

Antitoxin

Source ID Structure
AlphaFold DB A0A7L5MIC5

References