Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/StbC(antitoxin)
Location 642958..643323 Replicon chromosome
Accession NZ_CP053748
Organism Massilia sp. erpn

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HPQ68_RS02885 Protein ID WP_255756375.1
Coordinates 643174..643323 (+) Length 50 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HPQ68_RS02880 Protein ID WP_255756374.1
Coordinates 642958..643167 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPQ68_RS02860 (HPQ68_02855) 638177..639172 + 996 WP_050409266.1 BMP family ABC transporter substrate-binding protein -
HPQ68_RS02865 (HPQ68_02860) 639252..640781 + 1530 WP_255756372.1 ABC transporter ATP-binding protein -
HPQ68_RS02870 (HPQ68_02865) 640778..641860 + 1083 WP_255756373.1 ABC transporter permease -
HPQ68_RS02875 (HPQ68_02870) 641865..642836 + 972 WP_176347466.1 ABC transporter permease -
HPQ68_RS02880 (HPQ68_02875) 642958..643167 + 210 WP_255756374.1 DNA-binding protein Antitoxin
HPQ68_RS02885 643174..643323 + 150 WP_255756375.1 hypothetical protein Toxin
HPQ68_RS02890 (HPQ68_02885) 643414..645483 - 2070 WP_255756376.1 TonB-dependent receptor -
HPQ68_RS02895 (HPQ68_02890) 645580..646341 + 762 WP_255756377.1 response regulator transcription factor -
HPQ68_RS02900 (HPQ68_02895) 646360..646935 - 576 WP_255756378.1 NUDIX domain-containing protein -
HPQ68_RS02905 (HPQ68_02900) 647012..647767 + 756 WP_176347463.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5628.47 Da        Isoelectric Point: 8.7974

>T157698 WP_255756375.1 NZ_CP053748:643174-643323 [Massilia sp. erpn]
MYLLDTNVISEFRKGERAHPGVQRFFASVQSQLMFLPAHPRPEGLQSLQ

Download         Length: 150 bp

>T157698 NZ_CP069447:2858748-2859026 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGTAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8028.21 Da        Isoelectric Point: 5.0758

>AT157698 WP_255756374.1 NZ_CP053748:642958-643167 [Massilia sp. erpn]
MSQLLIRDLDDEIIIELKRQATANGRSAEAEHREILCNHLLPPFPKKRSFKEVLASMPYFGDDELFDVR

Download         Length: 210 bp

>AT157698 NZ_CP069447:2859026-2859310 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCTACGGCAAGTCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTGTCTGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References