Detailed information of TA system TA157692

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 235676..236181
• Replicon: chromosome
• Accession: NZ_CP053747
• Organism: Pseudomonas aeruginosa strain Pae1255-NDM1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HJ571_RS01090
• Protein ID: WP_034037564.1
• Coordinates: 235676..235957 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: HJ571_RS01095
• Protein ID: WP_003083775.1
• Coordinates: 235954..236181 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HJ571_RS01065 (HJ571_01075)	230927..232276	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
HJ571_RS01070 (HJ571_01080)	232325..233011	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
HJ571_RS01075 (HJ571_01085)	233112..233846	+	735	WP_003117208.1	GntR family transcriptional regulator	-
HJ571_RS01080 (HJ571_01090)	234026..234436	+	411	WP_003101225.1	aegerolysin family protein	-
HJ571_RS01085 (HJ571_01095)	234468..235376	-	909	WP_016561475.1	LysR family transcriptional regulator	-
HJ571_RS01090 (HJ571_01100)	235676..235957	-	282	WP_034037564.1	type II toxin-antitoxin system toxin ParE	Toxin
HJ571_RS01095 (HJ571_01105)	235954..236181	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
HJ571_RS01100 (HJ571_01110)	236357..236977	-	621	WP_034037566.1	hypothetical protein	-
HJ571_RS01105 (HJ571_01115)	237078..237578	+	501	WP_003101228.1	LEA type 2 family protein	-
HJ571_RS01110 (HJ571_01120)	237651..237992	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
HJ571_RS01115 (HJ571_01125)	238074..239501	-	1428	WP_003083784.1	GABA permease	-
HJ571_RS01120 (HJ571_01130)	239670..241163	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10458.20 Da
• Isoelectric Point: 10.0435

>T157692 WP_034037564.1 NZ_CP053747:c235957-235676 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T157692 NZ_CP069447:1523531-1523842 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCTTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATCACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT157692 WP_003083775.1 NZ_CP053747:c236181-235954 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT157692 NZ_CP069447:1523839-1524258 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCAGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCTTGACGATACCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9